Bradley Nelson
University of Michigan
5 Papers
139 Citations
Bradley Nelson is an academic researcher from University of Michigan. The author has contributed to research in topics: Acinar cell & Gel electrophoresis. The author has an hindex of 5, co-authored 5 publications.
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Papers
Organellar Proteomics Analysis of Pancreatic Zymogen Granule Membranes
Xuequn Chen,Angela K. Walker,John R. Strahler,Eric S. Simon,Sarah L. Tomanicek-Volk,Bradley Nelson,Mary C. Hurley,Stephen A. Ernst,John A. Williams,Philip C. Andrews +9 more
TL;DR: By combining subcellular fractionation with high resolution separation and comprehensive identification of proteins, this work has begun to elucidate zymogen granule functions through proteomic and subsequent functional analysis of its membrane components.
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The hepatic BMAL1/AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARα pathway.
Deqiang Zhang,Xin Tong,Bradley Nelson,Ethan Jin,Julian Sit,Nicholas Charney,Meichan Yang,M. Bishr Omary,Lei Yin +8 more
TL;DR: It is shown that the circadian clock protein BMAL1 in hepatocytes is both necessary and sufficient to protect mice from ALD and the protective action of BMAL 1 during alcohol consumption depends on its ability to couple ChREBP‐induced de novo lipogenesis with PPARα‐mediated fatty oxidation.
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SEC23B is required for pancreatic acinar cell function in adult mice
Rami Khoriaty,Nancy L. Vogel,Mark J. Hoenerhoff,M. Dolors Sans,Guojing Zhu,Lesley Everett,Bradley Nelson,Haritha Durairaj,Brooke McKnight,Bin Zhang,Stephen A. Ernst,David Ginsburg,John A. Williams +12 more
TL;DR: Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in loss of pancreatic mass, with evidence of cell loss, degeneration of exocrine cells, ER stress, and increased pancreatic cell apoptosis.
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A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress.
Jared S. Elenbaas,Dhiman Maitra,Yang Liu,Stephen I. Lentz,Bradley Nelson,Mark J. Hoenerhoff,Jordan A. Shavit,M. Bishr Omary +7 more
TL;DR: Systemic administration of the heme precursors PP‐IX or ALA+DFO into zebrafish larvae provides a new model of acute protoporphyria with consequent hepatocyte protein aggregation and proteotoxic multiorganelle alterations and stress.
22
Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F
Jared S. Elenbaas,Juliana Bragazzi Cunha,Rodrigo Azuero-Dajud,Bradley Nelson,Elif A. Oral,John A. Williams,Colin L. Stewart,M. Bishr Omary,M. Bishr Omary +8 more
TL;DR: It is shown that LMNA is lost from most exocrine pancreas cells, and LMNA-knockout pancreata have reduced levels of RB and activation of E2F, based on increased expression of E 2F target genes, which maintain pancreatic homeostasis by regulating RB stability and E1F activity.
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