Bradley J. Rabquer
University of Michigan
26 Papers
47 Citations
Bradley J. Rabquer is an academic researcher from University of Michigan. The author has contributed to research in topics: Angiogenesis & Medicine. The author has an hindex of 15, co-authored 26 publications. Previous affiliations of Bradley J. Rabquer include University of Toledo Medical Center & Albion College.
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Papers
Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production
Salahuddin Ahmed,Hubert Marotte,Kevin Kwan,Jeffrey H. Ruth,Phillip L. Campbell,Bradley J. Rabquer,Angela Pakozdi,Alisa E. Koch,Alisa E. Koch +8 more
TL;DR: It is found that epigallocatechin-3-gallate (EGCG), an anti-inflammatory compound found in green tea, inhibits IL-1β–induced IL-6 production and transsignaling in RA synovial fibroblasts by inducing alternative splicing of gp130 mRNA, resulting in enhanced sgp130 production.
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DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis
Nirit Mor-Vaknin,Anjan K. Saha,Maureen Legendre,Carmelo Carmona-Rivera,M. Asif Amin,Bradley J. Rabquer,Marta J Gonzales-Hernandez,Julie M. Jorns,Smriti Mohan,Srilakshmi Yalavarthi,Dave A. Pai,Kristine Angevine,Shelley J Almburg,Jason S. Knight,Barbara S. Adams,Alisa E. Koch,David A. Fox,David R. Engelke,Mariana J. Kaplan,David M. Markovitz +19 more
TL;DR: It is shown that DEK is crucial to the development of arthritis in mouse models, thus making it an appropriate target for aptamer-based therapy and anti-DEK aptamers hold promise for the treatment of JIA and other types of arthritis.
Junctional Adhesion Molecule-C Is a Soluble Mediator of Angiogenesis
Bradley J. Rabquer,Mohammad A. Amin,Nanditha Teegala,Matthew K. Shaheen,Pei-Suen Tsou,Jeffrey H. Ruth,Charles Lesch,Beat A. Imhof,Alisa E. Koch,Alisa E. Koch +9 more
TL;DR: The results show that JAM-C exists in soluble form and suggest that modulation of sJam-C may provide a novel route for controlling pathological angiogenesis.
Angiogenesis and Vasculopathy in Systemic Sclerosis: Evolving Concepts
Bradley J. Rabquer,Alisa E. Koch +1 more
TL;DR: The role that chemokine and growth factor receptors, proteases, adhesion molecules, and transcription factors play in the dysregulation of angiogenesis in SSc is examined.
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ADAM-10 is overexpressed in rheumatoid arthritis synovial tissue and mediates angiogenesis.
TL;DR: Data show that ADam-10 is overexpressed in RA and suggest that ADAM-10 may play a role in RA angiogenesis, which may be a potential therapeutic target in inflammatory angiogenic diseases such as RA.
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