Bradley Austin
University of Ottawa
11 Papers
10 Citations
Bradley Austin is an academic researcher from University of Ottawa. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 3 publications. Previous affiliations of Bradley Austin include Ottawa Hospital Research Institute.
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Papers
Single dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection
Stephen Boulton,Stephen Boulton,Joanna Poutou,Joanna Poutou,Nikolas T. Martin,Nikolas T. Martin,Taha Azad,Taha Azad,Ragunath Singaravelu,Ragunath Singaravelu,Mathieu J.F. Crupi,Mathieu J.F. Crupi,Taylor R Jamieson,Taylor R Jamieson,Xiaohong He,Xiaohong He,Ricardo Marius,Ricardo Marius,Julia Petryk,Julia Petryk,Christiano Tanese de Souza,Christiano Tanese de Souza,Bradley Austin,Bradley Austin,Zaid Taha,Zaid Taha,Jack Whelan,Jack Whelan,Sarwat T. Khan,Adrian Pelin,Adrian Pelin,Reza Rezaei,Reza Rezaei,Abera Surendran,Abera Surendran,Sarah Tucker,Sarah Tucker,Emily E.F. Brown,Emily E.F. Brown,Jaahnavi Dave,Jaahnavi Dave,Jean-Simon Diallo,Jean-Simon Diallo,Rebecca C. Auer,Rebecca C. Auer,Jonathan B. Angel,Jonathan B. Angel,Jonathan B. Angel,D. William Cameron,Jean-François Cailhier,Réjean Lapointe,Kyle Potts,Kyle Potts,Douglas J. Mahoney,Douglas J. Mahoney,John C. Bell,John C. Bell,Carolina S. Ilkow,Carolina S. Ilkow +58 more
TL;DR: To combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a temperature-stable vaccine candidate (TOH-Vac1) was proposed in this paper.
19
Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy
Nikolas T. Martin,Mathieu J.F. Crupi,Zaid Taha,Joanna Poutou,Jack Whelan,Sydney Vallati,Julia Petryk,Ricardo Marius,Bradley Austin,Taha Azad,Ilson D. Sanders,Bryan C. Dickinson,Jean-Simon Diallo,Carolina S. Ilkow,John C. Bell +14 more
TL;DR: In this article , an inducible expression system based on a Split-T7 RNA polymerase for oncolytic poxviruses was developed to regulate the spatial and temporal expression of a beneficial transgene.
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A T Cell-Targeted Multi-Antigen Poxvirus Vector Vaccine Generates Robust Cellular and Humoral Immunity Against SARS-CoV-2 Infection
Stephen Boulton,Joanna Poutou,Rida Gill,Nouf Alluqmani,Xiaohong He,Ragunath Singaravelu,Mathieu J.F. Crupi,Julia Petryk,Bradley Austin,Leonard Angka,Zaid Taha,Iris Teo,Siddarth Singh,Rameen Jamil,Ricardo Marius,Nikolas T. Martin,Taylor R Jamieson,Taha Azad,Jean-Simon Diallo,Carolina S. Ilkow,John C. Bell +20 more
TL;DR: The effectiveness of the second-generation vaccinia virus-based COVID-19 vaccine, TOH-VAC-2, encoded with modified versions of the spike (S) and nucleocapsid (N) proteins as well as a unique poly-epitope antigen that contains immunodominant T cell epitopes from seven different SARS-CoV-2 proteins is demonstrated.
3
Fatty acid transport protein inhibition sensitizes breast and ovarian cancers to oncolytic virus therapy via lipid modulation of the tumor microenvironment
Abera Surendran,Monire Jamalkhah,Joanna Poutou,Rayanna Birtch,Christine Lawson,Jaahnavi Dave,Mathieu J.F. Crupi,Justin Mayer,Victoria Taylor,Julia Petryk,Christiano Tanese de Souza,Neil Moodie,Jacob Lecompte Billingsley,Bradley Austin,Nicole Cormack,Natalie Blamey,Reza Rezaei,Curtis W McCloskey,Emily E. F. Fekete,Harsimrat Kaur Birdi,Serge Neault,Taylor R Jamieson,Brenna Wylie,Sarah Tucker,Taha Azad,Barbara C. Vanderhyden,Lee-Hwa Tai,John C. Bell,Carolina S. Ilkow +28 more
TL;DR: In this paper , the role of adipose tissue and adipocytes in response to oncolytic virus (OV) therapy in adipose-rich tumours such as breast and ovarian neoplasms was investigated.
CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX
J. T. Whelan,Ragunath Singaravelu,Fuan Wang,Adrian Pelin,Levi Tamming,Giuseppe Pugliese,Nikolas T. Martin,Mathieu J.F. Crupi,Julia Petryk,Bradley Austin,Xiaohong He,Ricardo Marius,Jessie Duong,Carter Jones,Emily E. F. Fekete,Nouf Alluqmani,Andrew Chen,Stephen Boulton,Michael S. Huh,Matt Y. Tang,Zaid Taha,Elena Scut,Jean-Simon Diallo,Taha Azad,Brian D. Lichty,Carolina S. Ilkow,John C. Bell +26 more
TL;DR: In this article , a simple modular CRISPR/Cas9 assisted-recombinant vaccinia virus engineering (CARVE) system was used to generate a recombinant vaccine vector expressing three distinct transgenes at three different loci in less than 1 week.