Glucocorticoids are well-known for their strong suppressive influence on certain cells of the immune system. These pharmacologic effects have long been taken advantage of to suppress immune responses and to treat leukemia and lymphomas. In recent years, a great deal has been learned of the mechanisms by which glucocorticoids affect lymphoid and related cells, and this information now provides a basis for studying the varying susceptibility to glucocorticoid therapy of the leukemias, lymphomas and myelomas in young and older patients. Expression of glucocorticoid receptors themselves is sometimes used as one predictive variable (Bloomfield, 1984; Thompson et al., 1985; Iacobelli et al., 1987). In this brief overview, we will outline the general pattern of expression with age of these groups of malignancies, discuss the recently established principles of glucocorticoid action, and describe some of our own experience with glucocorticoid effects on certain malignant lymphoid cell lines in vitro.

Glucocorticoid Receptors in Leukemias, Lymphomas and Myelomas of Young and Old

Genotype study of T receptors in the diagnosis and classification of leukemias and lymphomas

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Genotype study of T receptors in the diagnosis and classification of leukemias and lymphomas