Bonne M. Thompson
University of Texas Southwestern Medical Center
36 Papers
8 Citations
Bonne M. Thompson is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 17, co-authored 30 publications.
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Papers
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.
Jason S. Seidman,Ty D. Troutman,Mashito Sakai,Anita Gola,Nathanael J. Spann,Hunter Bennett,Cassi M. Bruni,Zhengyu Ouyang,Rick Z. Li,Xiaoli Sun,Bao Chau T. Vu,Martina P. Pasillas,Kaori M. Ego,David Gosselin,Verena M. Link,Ling Wa Chong,Ronald M. Evans,Bonne M. Thompson,Jeffrey G. McDonald,Mojgan Hosseini,Joseph L. Witztum,Ronald N. Germain,Christopher K. Glass +22 more
TL;DR: Findings reveal mechanisms by which disease-associated environmental signals instruct resident and recruited macrophages to acquire distinct gene expression programs and corresponding functions.
340
27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth
Qian Wu,Tomonori Ishikawa,Rosa Sirianni,Hao Tang,Jeffrey G. McDonald,Ivan S. Yuhanna,Bonne M. Thompson,Luc Girard,Chieko Mineo,Rolf A. Brekken,Michihisa Umetani,David M. Euhus,Yang Xie,Philip W. Shaul +13 more
TL;DR: It is reported that the cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice, and in ER+ breast cancer patients, 27HC content in normal breast tissue is increased compared to that in cancer-free controls, and tumor 27 HC content is further elevated.
340
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
David R. Bauman,Andrew Bitmansour,Jeffrey G. McDonald,Bonne M. Thompson,Guosheng Liang,David W. Russell +5 more
TL;DR: The suppression of IgA class switching in B cells by a macrophage-derived sterol in response to TLR activation provides a mechanism for local and systemic negative regulation of the adaptive immune response by the innate immune system.
325
Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.
Mashito Sakai,Ty D. Troutman,Jason S. Seidman,Zhengyu Ouyang,Nathanael J. Spann,Yohei Abe,Kaori M. Ego,Cassi M. Bruni,Zihou Deng,Johannes C. M. Schlachetzki,Alexi Nott,Hunter Bennett,Jonathan Chang,Bao Chau T. Vu,Martina P. Pasillas,Verena M. Link,Verena M. Link,Lorane Texari,Sven Heinz,Bonne M. Thompson,Jeffrey G. McDonald,Frederic Geissmann,Christopher K. Glass +22 more
TL;DR: Analysis of transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer cell depletion provides a framework for understanding how macrophage progenitor cells acquire tissue-specific phenotypes.
322
A Mouse Macrophage Lipidome
Edward A. Dennis,Raymond A. Deems,Richard Harkewicz,Oswald Quehenberger,H. Alex Brown,Stephen B. Milne,David S. Myers,Christopher K. Glass,Gary Hardiman,Donna Reichart,Alfred H. Merrill,M. Cameron Sullards,Elaine Wang,Robert C. Murphy,Christian R. H. Raetz,Teresa A. Garrett,Ziqiang Guan,Andrea C. Ryan,David W. Russell,Jeffrey G. McDonald,Bonne M. Thompson,Walter A. Shaw,Manish Sud,Yihua Zhao,Shakti Gupta,Mano Ram Maurya,Eoin Fahy,Shankar Subramaniam +27 more
TL;DR: The lipidomic response of the murine macrophage RAW cell line to Kdo2-lipid A, the active component of an inflammatory lipopolysaccharide functioning as a selective TLR4 agonist and compactin, a statin inhibitor of cholesterol biosynthesis is reported.
303