Bolin Deng
Chongqing Medical University
13 Papers
Bolin Deng is an academic researcher from Chongqing Medical University. The author has contributed to research in topics: Medicine & Genotype. The author has an hindex of 7, co-authored 9 publications.
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Papers
Genetic analysis of innate immunity in Behcet's disease identifies an association with IL-37 and IL-18RAP.
Handan Tan,Bolin Deng,Hongsong Yu,Yi Yang,Lin Ding,Qi Zhang,Jieying Qin,Aize Kijlstra,Rui Chen,Peizeng Yang +9 more
TL;DR: Functional studies performed in healthy controls showed that rs3811047 AG genotype carriers had a higher IL-37 gene expression in peripheral blood mononuclear cells (PBMCs) than GG carriers, and GG carriers showed a higher cytokine expression as compared to AG carriers.
Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese
Hongsong Yu,Minming Zheng,Lijun Zhang,Hua Li,Yunyun Zhu,Ling Cheng,Lin Li,Bolin Deng,Aize Kijlstra,Peizeng Yang +9 more
TL;DR: The findings not only confirmed the association of IL10/rs1800871 and IL23R‐IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL24490 and rs12141431 with BD in Han Chinese.
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Decreased B and T lymphocyte attenuator in Behcet's disease may trigger abnormal Th17 and Th1 immune responses.
TL;DR: In this article, the authors investigated whether B and T lymphocyte attenuator activation could be exploited to inhibit the development of abnormal immune responses in Behcet's disease (BD) patients and found that decreased BTLA level was associated with increased Th17 and Th1 responses.
Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma
Chong He,Wenbo Xiu,Qinyuan Chen,Kun Peng,Xiong Zhu,Zuo Wang,Xiang-shu Xu,Yangkang Chen,Gao-Yuan Zhang,Jing Fu,Qiwei Dong,Xiaoqiong Wu,An Li,Donghua Liu,Yanping Gao,Jin-Xia Wang,Zhao Wang,Bolin Deng,Ping Shuai,Caiping Gao,Yilian Chen,Ling Yu,Fang Lu +22 more
TL;DR: A role of gut-licensed β7+ CD4+ T cells and MAdCAM-1 in RGC degeneration is revealed and the importance of the “gut-retina” axis in glaucoma is emphasized.
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Decreased expression of A20 is associated with ocular Behcet's disease (BD) but not with Vogt-Koyanagi-Harada (VKH) disease.
Yue He,Chaokui Wang,Guannan Su,Bolin Deng,Zi Ye,Yang Huang,Gangxiang Yuan,Kijlstra Aize,Hong Li,Peizeng Yang +9 more
TL;DR: It is shown that the expression of A20 was decreased in BD patients with active uveitis but not in VKH disease, which may lead to an enhanced activation of proinflammatory Th17 cells, causing a reactivation of BD.
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