Bohumil Bednar
United States Military Academy
44 Papers
725 Citations
Bohumil Bednar is an academic researcher from United States Military Academy. The author has contributed to research in topics: Fibrinogen receptor & Receptor. The author has an hindex of 21, co-authored 44 publications. Previous affiliations of Bohumil Bednar include Merck & Co..
Chat about Author
Papers
Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization.
Neal C. Burton,Manishkumar Patel,Stefan Morscher,Wouter H. P. Driessen,Jing Claussen,Nicolas Beziere,Thomas Jetzfellner,Adrian Taruttis,Daniel Razansky,Bohumil Bednar,Vasilis Ntziachristos +10 more
TL;DR: It is found that multiparameter, multispectral imaging of the growth of U87 tumor cells injected into the brain could be visualized through the intact mouse head, for example through visualization of deoxygenated hemoglobin in the growing tumor.
146
An Antibody Against the Exosite of the Cloned Thrombin Receptor Inhibits Experimental Arterial Thrombosis in the African Green Monkey
Jacquelynn J. Cook,G. R. Sitko,Bohumil Bednar,Cindra L. Condra,M J Mellott,Dong-Mei Feng,Ruth F. Nutt,Jules A. Shafer,Robert J. Gould,Thomas M. Connolly +9 more
TL;DR: It is demonstrated that blockade of the platelet thrombin receptor can prevent arterial thrombosis in this animal model without significantly altering hemostatic parameters and suggest that the throm bin receptor is an attractive antithrombotic target.
102
Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT)
Sylvie Kossodo,Maureen Pickarski,Shu-An Lin,Alexa Gleason,Renee C. Gaspar,Chiara Buono,Guojie Ho,Agnieszka Blusztajn,Garry Cuneo,Jun Zhang,Jayme Jensen,Richard Hargreaves,Paul J. Coleman,George D. Hartman,Milind Rajopadhye,Le Thi Duong,Cyrille Sur,Wael Yared,Jeffrey D. Peterson,Bohumil Bednar +19 more
TL;DR: NIRF-labeled integrin antagonists allow noninvasive molecular fluorescent imaging and quantification of tumors in vivo, improving and providing more refined approaches for cancer detection and treatment monitoring.
93
NR2B-Selective N-Methyl-d-aspartate Antagonists: Synthesis and Evaluation of 5-Substituted Benzimidazoles
John A. McCauley,Cory R. Theberge,Joseph J. Romano,Susan B Billings,Kenneth D. Anderson,David A. Claremon,Roger M. Freidinger,Rodney A. Bednar,Scott D. Mosser,Stanley L. Gaul,Thomas M. Connolly,Cindra L. Condra,Menghang Xia,Michael E. Cunningham,Bohumil Bednar,Gary L. Stump,Joseph J. Lynch,Alison Macaulay,Keith A Wafford,Kenneth S. Koblan,Nigel J. Liverton +20 more
TL;DR: Two classes of 5-substituted benzimidazoles were identified as potent antagonists of the NR2B subtype of the N-methyl-d-aspartate (NMDA) receptor, and selected compounds show very good selectivity compared to other subtypes of the NMDA receptor.
63
Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa
Bohumil Bednar,Jacquelynn J. Cook,Marie A. Holahan,Michael E. Cunningham,Patricia A. Jumes,Rodney A. Bednar,George D. Hartman,Robert J. Gould +7 more
TL;DR: Flow cytometric analysis showed drug-dependent antibodies (DDAbs) in the plasma of chimpanzee A-264 that bound to platelets of chimpanzees, humans, and all other primates tested only in the presence of the compounds that induced thrombocytopenia.
61