Neocarzinostatin (NCZ), a new antitumor antibiotic, was administered to 19 patients with bladder cancer, 16 patients with prostatic cancer, and 3 patients with hepatoma All patients had objectively measurable metastatic lesions including 21 with palpable nodes or subcutaneous nodules, 10 with pulmonary nodules as demonstrated by chest x-ray, 4 with malignant hepatomegaly, and 3 with bidimensional pelvic masses as demonstrated by CT scanning Sixty-five courses of NCZ were administered via an intravenous bolus daily for five days with dosages ranging from 1500 to 3000 U/m2 Immediate toxicity was not dose-limiting except for 1 episode of anaphylaxis and 1 of acute renal failure Myelotoxicity was delayed, dose-dependent, noncumulative, and dose-limiting Thrombocytopenia was prolonged or irreversible in 5 cases The maximally tolerated dose was 2750 U/m2 One patient with NCZ-associated pulmonary fibrosis and 1 with biopsy-proven hepatitis are discussed in detail Neocarzinostatin demonstrated minimal therapeutic activity (1 partial remission) in patients with bladder cancer There was no response in patients with prostatic cancer or hepatoma

Phase II trial of neocarzinostatin in patients with bladder and prostatic cancer: toxicity of a five-day iv bolus schedule.

Fate and distribution of [14C] succinyl neocarzinostatin in rats.

Classification of Chemotherapeutic Agents According to their Mechanisms of Action

Suppression of graft-versus-host reaction by preincubation of the graft with an antitumor protein, neocarzinostatin.

Neocarzinostatin (NCS) is a protein antitumor antibiotic isolated from Streptomyces carzinostaticus, var 41. The drug is a polypeptide consisting of 109 amino acids (m.w. 10,700) linked by two disulfide bridges. The amino acid sequence has been determined by Meinhoffer [9]. NCS is the highest molecular weight antitumor antibiotic currently in clinical trials.

Neocarzinostatin: Initial Clinical and Pharmacologic Studies in the United States

Toxicity of neocarzinostatin (NSC-69856): an antitumor antibiotic with radiomimetic and antigenic characteristics.

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Toxicity of neocarzinostatin (NSC-69856): an antitumor antibiotic with radiomimetic and antigenic characteristics.