Bodo Scheiper
Max Planck Society
20 Papers
44 Citations
Bodo Scheiper is an academic researcher from Max Planck Society. The author has contributed to research in topics: Indole test & Total synthesis. The author has an hindex of 8, co-authored 20 publications.
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Papers
Selective Iron-Catalyzed Cross-Coupling Reactions of Grignard Reagents with Enol Triflates, Acid Chlorides, and Dichloroarenes
TL;DR: A detailed analysis of the preparative results suggests that iron-catalyzed C-C bond formations can occur via different pathways and it is likely that reactions of methylmagnesium halides involve iron-ate complexes as the active components, whereas reactions of Grignard reagents with two or more carbon atoms are effected by highly reduced iron-clusters of the formal composition [Fe(MgX)(2)](n) generated in situ.
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Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.
TL;DR: This work further explored the aspartyl protease renin motif by structure-based drug design guided by X-ray crystallography in combination with efficient parallel synthesis, resulting in the discovery of 4- or 6-azaindole derivatives with remarkable potency for renin inhibition.
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Discovery and Optimization of a New Class of Potent and Non-Chiral Indole-3-carboxamide-Based Renin Inhibitors.
Bodo Scheiper,Hans Mater,Henning Steinhagen,Ulrich Stilz,Z. Boecskei,Valérie Fleury,Gary Mccort +6 more
TL;DR: Compound (I) is found to be the most potent renin inhibitor without significant inhibition of related proteases.
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Identification and optimization of a new series of anti-tubercular quinazolinones.
Cédric Couturier,Christine Lair,Alain Pellet,Anna M. Upton,Takushi Kaneko,Corinne Perron,Eric Cogo,Jerome Menegotto,Armin Bauer,Bodo Scheiper,Sophie Lagrange,Eric Bacqué +11 more
TL;DR: A high throughput phenotypic screening against Mycobacterium smegmatis led to the discovery of a new class of bacteriostatic, highly hydrophobic antitubercular quinazolinones that potently inhibited the in vitro growth of either extracellular or intramacrophagic M. tuberculosis (Mtb), via modulation of an unidentified but yet novel target.
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Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: synthesis, biological evaluation and X-ray crystallographic studies.
Cédric Couturier,Sandra Silve,Renaud Morales,Bernard Pessegue,Sylvie Llopart,Anil Nair,Armin Bauer,Bodo Scheiper,Christoph Pöverlein,Axel Ganzhorn,Sophie Lagrange,Eric Bacqué +11 more
TL;DR: Despite possibly nanomolar inhibitions, none of these compounds was active on whole cell Mtb, suggesting that GlnA1 may not be a suitable target to find new anti-tubercular drugs.
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