Bodil Petersen
Leipzig University
9 Papers
64 Citations
Bodil Petersen is an academic researcher from Leipzig University. The author has contributed to research in topics: Lung injury & Endothelin receptor. The author has an hindex of 5, co-authored 9 publications.
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Papers
Inhalation of the ETA receptor antagonist LU-135252 selectively attenuates hypoxic pulmonary vasoconstriction
Bodil Petersen,Maria Deja,Roland Bartholdy,Bernd Donaubauer,Sven Laudi,Roland C. E. Francis,Willehad Boemke,Udo X. Kaisers,Thilo Busch +8 more
TL;DR: In the experimental model of HPV, the inhaled ET(A) receptor antagonist LU-135252 induced selective pulmonary vasodilation without adverse systemic hemodynamic effects.
22
•Journal Article
Low-dose inhalation of an endothelin-A receptor antagonist in experimental acute lung injury: ET-1 plasma concentration and pulmonary inflammation.
Bernd Donaubauer,Thilo Busch,Robert Lachmann,Maria Deja,Bodil Petersen,Roland C. E. Francis,Annette Träger,Michael Ebsen,Willehad Boemke,Udo Kaisers +9 more
TL;DR: In this animal model of ALI, inhalation of LU-135252 at a dose of 0.3 mg/kg induced a significant and sustained improvement in gas exchange, whereas there were no changes in ET-1 plasma concentrations.
13
Inhalation of the endothelin-A receptor antagonist LU-135252 at various doses in experimental acute lung injury.
Maria Deja,Thilo Busch,Steffen Wolf,Bernd Donaubauer,Bodil Petersen,Joerg Skomrock,Willehad Boemke,Udo Kaisers +7 more
TL;DR: It is concluded that inhalation of LU-135252 at either dose improved gas exchange and hemodynamics comparably, indicating that the lower dose was already sufficient to block the majority of endothelin-A receptors in ventilated regions of the injured lung.
10
Inhalation of an endothelin receptor A antagonist attenuates pulmonary inflammation in experimental acute lung injury.
Philipp Kalk,Philine SenfP. Senf,Maria Deja,Bodil Petersen,Thilo Busch,Christian Bauer,Willehad Boemke,U. Kaisers,Berthold Hocher +8 more
TL;DR: It is demonstrated that inhalation of LU 135252 not only improves mortality and gas exchange, but also blunts the local immune response in experimental ALI.
9
•Journal Article
Complement activation contributes to ventilator-induced lung injury in rats.
Bodil Petersen,Thilo Busch,J. Gaertner,Jack Haitsma,Stefan Krabbendam,Michael Ebsen,Burkhard Lachmann,Burkhard Lachmann,Udo X. Kaisers +8 more
TL;DR: It is concluded that in the animal model of VILI the complement system was activated in parallel with the impairment in arterial oxygenation and that pretreatment with 100 units/kg Berinert® did neither prevent systemic complement activation nor lung injury.