Bo Wu
Stanford University
18 Papers
2 Citations
Bo Wu is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 6 publications.
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Papers
Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites.
Tali Ilovitsh,Tali Ilovitsh,Yi Feng,Yi Feng,Josquin Foiret,Azadeh Kheirolomoom,Azadeh Kheirolomoom,Hua Zhang,Hua Zhang,Elizabeth S. Ingham,Asaf Ilovitsh,Asaf Ilovitsh,Spencer K. Tumbale,Brett Z. Fite,Bo Wu,Marina Nura Raie,Nisi Zhang,Aris J Kare,Michael Chavez,Lei S. Qi,Gadi Pelled,Dan Gazit,Ophir Vermesh,Idan Steinberg,Sanjiv S. Gambhir,Katherine W. Ferrara +25 more
TL;DR: Combined with intraperitoneal administration of checkpoint inhibition, a single application of IFN-β plasmid transfection reduced tumor growth in vivo and recruited efficacious immune cells at both the local and distant tumor sites.
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Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy.
Hua Zhang,Wei-Lun Tang,Azadeh Kheirolomoom,Brett Z. Fite,Bo Wu,Kenneth Lau,Mo Baikoghli,Marina Nura Raie,Spencer K. Tumbale,Josquin Foiret,Elizabeth S. Ingham,Lisa M. Mahakian,Sarah M. Tam,R. Holland Cheng,Alexander D. Borowsky,Katherine W. Ferrara +15 more
TL;DR: Systemic delivery of R848-TSLs, combined with local hyperthermia and αPD-1, inhibited tumor growth and extended median survival from 28 days (no-treatment control) to 94 days, resulting in tumor regression and enhanced survival when combined with αPD
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Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation.
Jai Woong Seo,Jai Woong Seo,Elizabeth S. Ingham,Lisa M. Mahakian,Spencer K. Tumbale,Bo Wu,Sadaf Aghevlian,Shahin Shams,Mo Baikoghli,Poorva Jain,Xiaozhe Ding,Nick Goeden,Tatyana Dobreva,Nicholas C. Flytzanis,Michael Chavez,Kratika Singhal,Ryan D. Leib,Michelle L. James,David J. Segal,R. Holland Cheng,Eduardo A. Silva,Viviana Gradinaru,Katherine W. Ferrara +22 more
TL;DR: The authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and image the brain accumulation of the PHP.eB capsid by PET, suggesting that novel PET imaging techniques can be applied to inform and optimize capsid design.
Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs.
Jai Woong Seo,Javier Ajenjo,Bo Wu,Elise Robinson,Marina Nura Raie,James Wang,Spencer K. Tumbale,Pablo Buccino,David A. Anders,Bin Shen,Frezghi Habte,Corinne Beinat,Michelle L. James,Samantha T. Reyes,Ravindra Kumar Sripriya,Timothy F. Miles,Jason T. Lee,Viviana Gradinaru,Katherine W. Ferrara +18 more
TL;DR: In this article , the authors used PET and positron emission tomography (PET) imaging of reporter genes and capsid tags to assess the temporal and spatial distribution and transduction of adeno-associated viruses (AAVs).
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PET imaging of focused-ultrasound enhanced delivery of AAVs into the murine brain
Javier Ajenjo,Jai Woong Seo,Josquin Foiret,Bo Wu,Marina Nura Raie,James Wang,Brett Z. Fite,Nisi Zhang,Rim Malek,Corinne Beinat,Noeen Malik,David A. Anders,Katherine W. Ferrara +12 more
TL;DR: Combining microbubbles with US-guided treatment facilitated a multi-hour BBB disruption and stable AAV transduction in targeted areas of the murine brain and has the potential to provide insight and aid in the translation of AAV-based therapies for the treatment of neuropathologies.
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