11 Papers
Bo Wu is an academic researcher from China Medical University (PRC). The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 3, co-authored 8 publications.
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Papers
Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers.
Bowen Li,Liang Yang,Xueqiang Peng,Qin Fan,Shibo Wei,Shuo Yang,Xinyu Li,Hongyuan Jin,Bo Wu,Mingyao Huang,Shilei Tang,Jingang Liu,Hangyu Li +12 more
TL;DR: This review focuses on the intrinsic cellular regulators against ferroptosis in cancer resistance, such as GPX4, NRF2 and the thioredoxin system, and the application of novel compounds and drugs to circumvent treatment resistance.
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Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer
Hongyuan Jin,Yuanxin Tang,Liang Yang,Xueqiang Peng,Bowen Li,Qin Fan,Shibo Wei,Shuo Yang,Xinyu Li,Bo Wu,Mingyao Huang,Shilei Tang,Jingang Liu,Hangyu Li +13 more
TL;DR: In this paper, the authors describe the characteristics of Rab GTPases and discuss the role of their activation in the regulation of membrane transport and provide examples of RabGTPases regulating membrane transport in tumor progression.
CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma.
Bowen Li,Shibo Wei,Liang Yang,Xueqiang Peng,Yingbo Ma,Bo Wu,Qing Fan,Shuo Yang,Xinyu Li,Hongyuan Jin,Shilei Tang,Mingyao Huang,Hangyu Li,Jingang Liu +13 more
TL;DR: In this article, a new role for CISD2 in sorafenib resistance in hepatocellular carcinoma (HCC) was shown, where the authors used quantitative real-time PCR (qPCR) to detect gene expression.
IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells.
Xueqiang Peng,Liang Yang,Yingbo Ma,Xinyu Li,Shuo Yang,Yan Li,Bo Wu,Shilei Tang,Fuhui Zhang,Bing Zhang,Jingang Liu,Hangyu Li +11 more
TL;DR: It is shown that constitutively active IKKβ subunits (CA-IKKβ) drives the formation and transport of amphisomes, thereby regulating tumor cell homeostasis, which may illuminate a special survival mechanism in tumor cells under stress.
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Autonomous glucose metabolic reprogramming of tumour cells under hypoxia: opportunities for targeted therapy
Mingyao Huang,Liang Yang,Xueqiang Peng,Shibo Wei,Qing Fan,Shuo Yang,Xinyu Li,Bowen Li,Hongyuan Jin,Bo Wu,Jingang Liu,Hangyu Li +11 more
TL;DR: The established and recently discovered autonomous molecular mechanisms that can induce cell reprogramming of hypoxic glucose metabolism in tumors are summarized and opportunities for targeted therapy are explored.