16 Papers
18 Citations
Bo Chen is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Cartilage & Bone remodeling. The author has an hindex of 8, co-authored 13 publications.
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Papers
Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.
Xianding Sun,Yang Zhou,Ruobin Zhang,Zuqiang Wang,Meng Xu,Dali Zhang,Junlan Huang,Fengtao Luo,Fangfang Li,Zhenhong Ni,Siru Zhou,Hangang Chen,Shuai Chen,Liang Chen,Xiaolan Du,Bo Chen,Haiyang Huang,Peng Liu,Liangjun Yin,Juhui Qiu,Di Chen,Chu-Xia Deng,Chu-Xia Deng,Yangli Xie,Lingfei Luo,Lin Chen +25 more
TL;DR: It is demonstrated that loss of dstyk leads to scoliosis in zebrafish due to dysregulated biogenesis of notochord vacuoles and that DSTYK is required for lysosome biogenesis through mTORC1 regulation.
Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia
Yangli Xie,Nan Su,Min Jin,Huabing Qi,Junbao Yang,Can Li,Xiaolan Du,Fengtao Luo,Bo Chen,Yue Shen,Haiyang Huang,Cory J. Xian,Chu-Xia Deng,Lin Chen +13 more
TL;DR: It is shown that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice and it is found that the PTH treatment can improve the osteopenia and bone structure of A CH mice.
A novel FGFR1-binding peptide attenuates the degeneration of articular cartilage in adult mice.
Qiaoyan Tan,Bo Chen,Quan Wang,Wei Xu,Yue Wang,Z. Lin,Fengtao Luo,Shuo Huang,Ying Zhu,Nan Su,Min Jin,Can Li,Liang Kuang,Huabing Qi,Zhenhong Ni,Zuqiang Wang,Xiaoqing Luo,Wanling Jiang,Hangang Chen,Shuai Chen,Fangfang Li,Bin Zhang,Junlan Huang,Ruobin Zhang,K. Jin,Xiaoling Xu,Chu-Xia Deng,Xiaolan Du,Yangli Xie,Li Chen +29 more
TL;DR: R1-P1, a novel inhibitory peptide for FGFR1, attenuates the degeneration of articular cartilage in adult mice, which is a potential leading molecule for the treatment of OA.
22
Network-based pharmacology and in vitro validation reveal that galangin induces apoptosis in bladder cancer cells by promoting the p53 signaling pathway.
Xiaoming Long,Li Chen,Jing Yang,Taotao Dong,Qisen Cheng,Wei-wei Wang,Yujian Zou,Yao Su,Wenbin Dai,Bo Chen,Xin Zhou +10 more
TL;DR: In vitro experiments showed that galangin could inhibit bladder cancer cell proliferation, induce apoptosis, and up- Regulate the expression of apoptosis-related proteins bax and Cleaved-PARP and down-regulate theexpression of Bcl-2; meanwhile, galangIn could promote the up-regulation of the expressionof p53 and cytc proteins through activating the p53 signaling pathway.
15
PTH 1-34 Ameliorates the Osteopenia and Delayed Healing of Stabilized Tibia Fracture in Mice with Achondroplasia Resulting from Gain-Of-Function Mutation of FGFR3.
Hangang Chen,Xianding Sun,Liangjun Yin,Shuai Chen,Ying Zhu,Junlan Huang,Wanling Jiang,Bo Chen,Ruobin Zhang,Lin Chen,Mao Nie,Yangli Xie,Zhong-Liang Deng +12 more
TL;DR: It is revealed that FGFR3 delays the regeneration of stabilized fracture by inhibiting both the chondrogenesis and osteogenesis, and PTH1-34 treatment can improve the dysregulated bone metabolism and delayed bone injury healing resulting from gain-of-function mutation ofFGFR3.