Previous Contributors Preface to Volume 1 Preface to Volume 6 Bernard W. Agranoff Emilio Bizzi Marian Cleeves Diamond Charles G. Gross Richard Held Leslie L. Iversen Masakazu Konishi Lawrence Kruger Susan E. Leeman Vernon B. Mountcastle Shigetada Nakanishi Solomon H. Snyder Nobuo Suga Hans Thoenen Index of Names

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The history of neuroscience in autobiography

Discriminating between reward and performance: a critical review of intracranial self-stimulation methodology.

Suction lesions of the frontal cerebral cortex in the rat induce asymmetrical behavioral and catecholaminergic responses.

A microcomputer-based method for physiologically interpretable measurement of the rewarding efficacy of brain stimulation.

Suction lesions of the right frontal cerebral cortex in rats induce a period of spontaneous hyperactivity. The hyperactivity, as measured by an increase in running wheel activity begins about one week post-operatively and continues throughout the remainder of a 30-day observation period. The increased activity is accompanied by a bilateral decrease in norepinephrine concentrations in both the ipsilateral and contralateral cortex and locus coeruleus. Identical lesions of the left frontal cerebral cortex produce neither the hyperactivity nor a decrease in norepinephrine concentrations. These experiments have reproduced many of the behavioral and biochemical asymmetries seen after middle cerebral artery ligation; however, suction lesions are both simpler to produce and histologically less variable in their effects.

Suction lesions of the frontal cerebral cortex in the rat induce asymmetrical behavioral and catecholaminergic responses

Bioplar stimulating electrodes were placed bilaterally in the posterior hypothalamus of rats following which the animals were shaped for intracranial self-stimulation (ICSS). When ICSS rates were stable for 1 wk, the right middle cerebral artery was ligated. During the 25-day postinfarction period, the rate of ICSS at specified current values was compared with preoperative rates. At 2 days after operation, there was a 33% decrease in the maximum frequency of ipsilateral ICSS. However, by 8 days after experimental stroke, there was a 16% increase in the maximal rate of ICSS above the preoperative value, and the rate returned to control levels by 20 days after surgery. The minimum current necessary to elicit the maximal rate of response also changed in a biphasic manner, i.e., the minimum required current was greater than preoperative control levels until 8 days after operation but then dropped below control level until 20 days postoperatively. There were no changes in the current or rate of response in the contralateral electrode. These results are discussed in relation to what may be the underlying neurophysiological changes causing these biphasic alterations in ICSS.

Changes in posterior hypothalamic self-stimulation following experimental cerebral infarction in the rat.

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Changes in posterior hypothalamic self-stimulation following experimental cerebral infarction in the rat.