Blayne A. Sayed
Emory University
30 Papers
60 Citations
Blayne A. Sayed is an academic researcher from Emory University. The author has contributed to research in topics: Medicine & Transplantation. The author has an hindex of 11, co-authored 15 publications. Previous affiliations of Blayne A. Sayed include Emory University Hospital & University of Cambridge.
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Papers
Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment?
TL;DR: It is proposed that neutrophils in turn promote the blood-brain barrier breach and together with T cells lead to further inflammatory cell influx and myelin damage, providing specific targets for intervention in multiple sclerosis as well as other immune-mediated CNS diseases.
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Preemptive kidney transplantation is associated with survival benefits among pediatric patients with end-stage renal disease.
TL;DR: Preemptive transplantation is associated with substantial benefits in allograft and patient survival among children with ESRD, particularly when compared with children who receive dialysis for >1 year, and policies to promote early access to transplantation and avoidance of dialysis whenever feasible are supported.
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Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
Nobuhiko Kayagaki,Irma B. Stowe,Kamela O. Alegre,Ishan Deshpande,Shuang Wu,Zhonghua Lin,Opher S. Kornfeld,Bettina L. Lee,Juan Zhang,John Liu,Eric Suto,Wyne P. Lee,Kellen Schneider,Wei Yu Lin,Dhaya Seshasayee,Tushar Bhangale,Cecile Chalouni,Matthew C. Johnson,Jan Mossemann,Neil A. Goldenberg,Blayne A. Sayed,Benjamin E. Steinberg,Kim Newton,Joshua D. Webster,Ryan L. Kelly,Vishva M. Dixit +25 more
TL;DR: In this paper , an anti-NINJ1 monoclonal antibody was developed to prevent NINJ 1 from forming oligomeric filaments, which may limit the inflammation that is associated with excessive cell death.
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Cutting Edge: Mast Cells Regulate Disease Severity in a Relapsing–Remitting Model of Multiple Sclerosis
TL;DR: It is confirmed that MC influence is not confined to an isolated model of EAE and revealed a new system to study the effects of MC heterogeneity on relapsing–remitting Eae and other SJL strain-specific diseases.
Racial and Ethnic Differences in Pediatric Access to Preemptive Kidney Transplantation in the United States
TL;DR: Future efforts to promote equity in preemptive transplant should address the critical issues of improving access to pre‐ESRD nephrology care and overcoming barriers in living donation, including obstacles partially driven by poverty.
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