Biswajit K. Singh
Central Drug Research Institute
15 Papers
203 Citations
Biswajit K. Singh is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Ascorbic acid & Organic synthesis. The author has an hindex of 8, co-authored 15 publications.
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Papers
Preparation and reactions of sugar azides with alkynes: synthesis of sugar triazoles as antitubercular agents.
Biswajit K. Singh,Amit Kumar Yadav,Brijesh Kumar,Anil N. Gaikwad,Sudhir Sinha,Vinita Chaturvedi,Rama Pati Tripathi +6 more
TL;DR: The synthesized sugar triazoles were evaluated for their antitubercular activity against Mycobacterium tuberculosis H37Rv, where one of the compounds displayed mild antitubcular activity in vitro with MIC 12.5 microg/mL.
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NAD(+)-dependent DNA ligase: a novel target waiting for the right inhibitor.
Namrata Dwivedi,Divya Dube,Jyoti Pandey,Biswajit K. Singh,Vandna Kukshal,Ravishankar Ramachandran,Rama P. Tripathi +6 more
TL;DR: NAD+‐dependent ligases show great promise and represent a novel drug target whose time has come and are addressed in the quest for optimized inhibitors of the enzyme.
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NAD+‐Dependent DNA Ligase: A Novel Target Waiting for the Right Inhibitor
Namrata Dwivedi,Divya Dube,Jyoti Pandey,Biswajit K. Singh,Vandna Kukshal,Ravishankar Ramachandran,Rama P. Tripathi +6 more
TL;DR: In this article, a review of the current structural work on DNA ligases is presented, and the currently available classes of inhibitors are described and modalities to improve the specificity and potencies of new inhibitors identified using protein structure based rational approaches.
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An elegant and unprecedented approach to 2-methylbenzofurans
TL;DR: In this article, an effective route for the synthesis of a variety of 2-methylbenzofurans is reported via DBU catalyzed dehydroiodination of easily accessible 2-iodomethyl-2,3-dihydrobenz ofurans, which could be easily obtained by water mediated iodocyclization of allyl phenols.
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Recent developments in search of antifilarial agents.
TL;DR: Different strategies to control this disease have been discussed with major emphasis on the mechanisms, merits and demerits of the existing drugs and the drugs under pipeline, and new antifilarial prototypes discovered recently.
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