Birgit Czermin
Ludwig Maximilian University of Munich
5 Papers
19 Citations
Birgit Czermin is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Histone methyltransferase & Histone code. The author has an hindex of 5, co-authored 5 publications.
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Papers
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.
TL;DR: Histone H3 methylated in vitro by the E(Z)/ESC complex binds specifically to Polycomb protein, which is closely associated with Polycomb binding sites on polytene chromosomes but is also found in centric heterochromatin, chromosome 4, and telomeric sites.
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The N-Terminus of Drosophila SU(VAR)3−9 Mediates Dimerization and Regulates Its Methyltransferase Activity†
TL;DR: The dimerization of dSU(VAR)3-9 and the subsequent increase of its methyltransferase activity provide a starting point to understand the molecular details of the formation of heterochromatic structures in vivo.
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ESC, ESCL and their roles in Polycomb Group mechanisms.
TL;DR: Both genes can sustain normal development in the absence of the other except for the critical role provided by maternal esc product in early embryonic development, which is shown to lead first to a loss of histone H3 K27 methylation and only at a later stage to a gradual loss of PRC1 binding to chromatin.
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The sounds of silence--histone deacetylation meets histone methylation.
Birgit Czermin,Axel Imhof +1 more
TL;DR: The physical association of two enzymatic activities, histone methylation and histone deacetylation, provide the framework of a molecular model of how heterochromatin is initiated and maintained during cell division and differentiation.
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Physical and functional association of SU(VAR)3-9 and HDAC1 in Drosophila.
Birgit Czermin,Gunnar Schotta,Bastian B. Hülsmann,Alexander Brehm,Peter B. Becker,Gunter Reuter,Axel Imhof +6 more
TL;DR: A model in which the concerted histone deacetylation and methylation by a SU(VAR)3‐9/HDAC1‐containing complex leads to a permanent silencing of transcription in particular areas of the genome is suggested.