Birgit Andersson
AstraZeneca
8 Papers
248 Citations
Birgit Andersson is an academic researcher from AstraZeneca. The author has contributed to research in topics: Repolarization & Antiarrhythmic agent. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Birgit Andersson include Astra.
Chat about Author
Papers
•Journal Article
Electrophysiological Characterization of the Prokinetic Agents Cisapride and Mosapride in Vivo and in Vitro: Implications for Proarrhythmic Potential?
TL;DR: It is concluded that the electrophysiological characteristics of cisapride may explain the recently reported propensity to prolong the QT interval and to induce torsades de pointes in susceptible patients, although a structurally related benzamide, mosapride, did not appear to have electrophYSiological features of relevance for induction of torsade de pointe in common with cisAPride.
170
Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes.
Malin K.B. Jonsson,Göran Duker,Charlotte Tropp,Birgit Andersson,Peter Sartipy,Marc A. Vos,Toon A.B. van Veen +6 more
TL;DR: The proarrhythmic results are qualitatively and quantitatively comparable between hESC-CMs and rabbit PF and indicate that additional validation of this new safety pharmacology model is warranted.
66
Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre.
TL;DR: Excessive action potential duration prolongation induced by E-4031 was attenuated by AZD7009 and lidocaine in rabbit Purkinje fibre, but not in atrial or ventricular tissue, most likely by inhibiting the late sodium current.
58
The combined ion channel blocker AZD1305 attenuates late Na current and IKr-induced action potential prolongation and repolarization instability.
TL;DR: By blocking INalate, AZD1305 attenuates excessive APD90 prolongation and repolarization instability following sudden slowing of rhythm implying a low proarrhythmic potential for AZD 1305.
14
Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel
Roine I. Olsson,Ingemar Jacobson,Tommy Iliefski,Jonas Boström,Öjvind Davidsson,Ola Fjellström,Annika Björe,Christina Olsson,Johan Sundell,Ulrik Gran,Jonna Gyll,Jesper Malmberg,Olle Hidestål,Hans Emtenäs,Tor Svensson,Zhong-Qing Yuan,Gert Strandlund,Annika Åstrand,Emma Lindhardt,Gunilla Linhardt,Elin Forsström,Ågot Högberg,Frida Persson,Birgit Andersson,Anna Rönnborg,Boel Löfberg +25 more
TL;DR: In vitro structure-activity relationships from lead structure C to optimized structure 3y were described and compound 3y was found to selectively prolong the atrial effective refractory period at submicromolar concentrations.
9