64 Papers
117 Citations
Binod Kumar is an academic researcher from Rosalind Franklin University of Medicine and Science. The author has contributed to research in topics: Virus & Biology. The author has an hindex of 15, co-authored 55 publications. Previous affiliations of Binod Kumar include University of Delhi & Loyola University Chicago.
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Papers
Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses.
Mairaj Ahmed Ansari,Sujoy Dutta,Mohanan Valiya Veettil,Dipanjan Dutta,Jawed Iqbal,Binod Kumar,Arunava Roy,Leela Chikoti,Vivek Vikram Singh,Bala Chandran +9 more
TL;DR: These studies identify the increased nuclear acetylation of IFI16 as a dynamic essential post-genome recognition event in the nucleus that is common to the IFI 16-mediated innate responses of inflammasome induction and IFN-β production during herpesvirus (KSHV, EBV, HSV-1) infections.
Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency.
Arunava Roy,Dipanjan Dutta,Jawed Iqbal,Gina Pisano,Olsi Gjyshi,Mairaj Ahmed Ansari,Binod Kumar,Bala Chandran +7 more
TL;DR: It is demonstrated that knockdown of IFI16 in the latently KSHV-infected B-lymphoma BCBL-1 and BC-3 cell lines results in lytic reactivation and increases in levels of K SHV lytic transcripts, proteins, and viral genome replication.
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KSHV Entry and Trafficking in Target Cells—Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics
Binod Kumar,Bala Chandran +1 more
TL;DR: This review summarizes the accumulated studies demonstrating that KSHV manipulates the host signal pathways to enter and traffic in the cytoplasm of the target cells, to deliver the viral genome into the nucleus, and initiate viral gene expression.
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Dynamics of SARS-CoV-2 Spike Proteins in Cell Entry: Control Elements in the Amino-Terminal Domains.
TL;DR: In this article, the authors constructed indels and substitutions within hypervariable NTD regions and used severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus-like particles and quantitative virus-cell entry assays to elucidate spike structures controlling initial infection stage.
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Assembly and Entry of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2): Evaluation Using Virus-Like Particles.
TL;DR: In this article, a nanoluciferase (Nluc) fragment complementation was used to track assembly and entry of SARS-CoV2 virus-like particles.
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