Bingxi Li
Chinese Academy of Sciences
17 Papers
8 Citations
Bingxi Li is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Biology & Innate immune system. The author has an hindex of 6, co-authored 11 publications.
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Papers
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy.
Qiyao Chai,Xudong Wang,Lihua Qiang,Yong Zhang,Pupu Ge,Zhe Lu,Yanzhao Zhong,Bingxi Li,Jing Wang,Lingqiang Zhang,Dawang Zhou,Wei Li,Wenzhu Dong,Yu Pang,George F. Gao,Cui Hua Liu +15 more
TL;DR: These findings reveal a unique mechanism of host xenophagy triggered by direct binding of ubiquitin to the pathogen surface protein, and indicate a diplomatic strategy adopted by Mtb to benefit its persistent intracellular infection through controlling intracesllular bacterial loads and restricting host inflammatory responses.
A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin
Qiyao Chai,Shanshan Yu,Yanzhao Zhong,Zhe Lu,Chang-Wei Qiu,Yang Yu,Xinwen Zhang,Yong Qiang Zhang,Zehui Lei,Li Qing,Bingxi Li,Yu Pang,Xiao-Bo Qiu,Jing Wang,Cui Hua Liu +14 more
TL;DR: The known proteinosphatase PtpB from Mycobacterium tuberculosis is identified as a phospholipid phosphatase inhibiting the host inflammasome-pyroptosis pathway and enhanced host GSDMD-dependent immune responses and reduced intracellular pathogen survival.
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M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival
Pupu Ge,Zehui Lei,Yang Yu,Zhe Lu,Lihua Qiang,Qiyao Chai,Yong Zhang,Dongdong Zhao,Bingxi Li,Yu Pang,Cui Hua Liu,Jing Wang +11 more
TL;DR: In this paper, the eukaryotic-type protein kinase G (PknG) prevented the activation of AKT via competitively binding to its pleckstrin homology (PH) domain, leading to autophagy induction.
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Mycobacterium tuberculosis Mce3E Suppresses Host Innate Immune Responses by Targeting ERK1/2 Signaling
TL;DR: It is demonstrated that M. tuberculosis Mce3E inhibits the activation of the ERK1/2 signaling pathway, leading to the suppression of Tnf and Il6 expression, and the promotion of mycobacterial survival within macrophages.
A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination
Li Qing,Yong Qiang Zhang,Zehui Lei,Zhe Lu,Shasha Tan,Pupu Ge,Qiyao Chai,Mengyuan Zhao,Xinwen Zhang,Bingxi Li,Yu Pang,Lingqiang Zhang,Cui Hua Liu,Jing Wang +13 more
TL;DR: In this article , the authors identify that protein tyrosine phosphatase A (PtpA), an effector secreted by tuberculosis (TB)-causing pathogen Mycobacterium tuberculosis (Mtb), triggers ferroptosis to promote Mtb pathogenicity and dissemination.