Bingbing Dai
University of Texas MD Anderson Cancer Center
6 Papers
Bingbing Dai is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Vascular endothelial growth factor A & Glioma. The author has an hindex of 4, co-authored 6 publications.
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Papers
FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes.
Bingbing Dai,Russell O. Pieper,Dawei Li,Ping Wei,Mingguang Liu,Shiao Y. Woo,Kenneth Aldape,Raymond Sawaya,Keping Xie,Suyun Huang +9 more
TL;DR: The results indicate that overexpression of FoxM1B, in cooperation with p53 and pRB inhibition in NHA cells, promotes astrocyte transformation and GBM formation through multiple mechanisms.
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Forkhead Box M1 Is Regulated by Heat Shock Factor 1 and Promotes Glioma Cells Survival under Heat Shock Stress
Bingbing Dai,Aihua Gong,Zhitao Jing,Kenneth Aldape,Shin Hyuk Kang,Raymond Sawaya,Suyun Huang +6 more
TL;DR: This study found that FoxM1 was up-regulated by heat shock factor 1 (HSF1) under heat shock stress condition in multiple cell lines and demonstrated a novel mechanism of stress resistance controlled by HSF1 and a new HSF-FoxM1 connection that mediates cellular thermotolerance.
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Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Liang Yan,Bo Tu,Jun Yao,Jing Gong,Alessandro Carugo,Christopher A. Bristow,Qiuyun Wang,Cihui Zhu,Bingbing Dai,Ya'an Kang,Leng Han,Ningping Feng,Yanqing Jin,Jason B. Fleming,Timothy P. Heffernan,Wantong Yao,Haoqiang Ying +16 more
TL;DR: This article investigated the requirement of these pathways for tumor maintenance using an inducible KrasG12D-driven PDAC mouse model (iKras model), identifying that RAF-MEK-MAPK signaling is the major effector for oncogenic KRAS-mediated tumor maintenance.
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Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition
Liang Yan,Bo Tu,Jun Yao,Jing Gong,Alessandro Carugo,Christopher A. Bristow,Qiuyun Wang,Cihui Zhu,Bingbing Dai,Ya'an Kang,Leng Han,Ningping Feng,Yanqing Jin,Jason B. Fleming,Timothy P. Heffernan,Wantong Yao,Haoqiang Ying +16 more
TL;DR: In this paper, the authors used an inducible KrasG12D-driven p53 deficient PDAC mouse model (iKras model) and demonstrated that RAF-MEK-MAPK signaling is the major effector for oncogenic Kras-mediated tumor maintenance.
FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells
TL;DR: It is found that vascular endothelial growth factor (VEGF) is a direct transcriptional target of FoxM1B and contributes to glioma progression by enhancing VEGF gene transcription and thus tumor angiogenesis.