Bing Xu
Shandong University
7 Papers
Bing Xu is an academic researcher from Shandong University. The author has contributed to research in topics: DNA damage & Cancer. The author has an hindex of 7, co-authored 7 publications.
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Papers
Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage.
Zhaojian Liu,Qiao Liu,Bing Xu,Jingjing Wu,Chun Guo,Faliang Zhu,Qiaozi Yang,Guimin Gao,Yaoqin Gong,Changshun Shao,Changshun Shao +10 more
TL;DR: One major mechanism by which berberine exerts its growth-inhibitory effect is to inflict genomic lesions on cells, which in turn trigger the activation of p53 and the p53-dependent cellular responses including cell cycle arrest and apoptosis.
143
Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51.
Qiao Liu,Haiyan Jiang,Zhaojian Liu,Yu Wang,Minnan Zhao,Chunyan Hao,Shuai Feng,Haiyang Guo,Bing Xu,Qifeng Yang,Yaoqin Gong,Changshun Shao +11 more
TL;DR: Berberine can effectively downregulate RAD51 in conferring radiosensitivity on esophageal cancer cells, and its clinical application as an adjuvant in chemotherapy and radiotherapy of esphageal cancers should be explored.
Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization
TL;DR: It is found that neferine possessed a potent growth-inhibitory effect on human osteosarcoma cells, but not on non-neoplastic human osteoblast cells, suggesting that consumption of neferines may have cancer-preventive and cancer-therapeutic benefit.
78
Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage.
Haiyang Guo,Zhaojian Liu,Bing Xu,Huili Hu,Zhao Wei,Qiao Liu,Xiyu Zhang,Xuebin Ding,Yu Wang,Minnan Zhao,Yaoqin Gong,Changshun Shao,Changshun Shao +12 more
TL;DR: CXCR2 is reported to be upregulated in various types of cells in response to genotoxic or oxidative stress and shown to be a critical mediator of cellular senescence downstream of p53 in Response to DNA damage.
55
Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction
Bing Xu,Wenxing Wang,Haiyang Guo,Zhaoliang Sun,Zhao Wei,Xiyu Zhang,Zhaojian Liu,Jay A. Tischfield,Yaoqin Gong,Changshun Shao,Changshun Shao +10 more
TL;DR: It is demonstrated that the induction of MN-γ-H2AX (+) by replication stress can also be attenuated by NAC, and that H2O2 also leads to increased phosphorylation of Chk1 and Rad17 that mimics replication stress, suggesting that replication stress and oxidative stress are intertwined and may reinforce each other in driving genomic instability.