5 Papers
75 Citations
Bing Lu is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Gene & Herpes simplex virus. The author has an hindex of 4, co-authored 4 publications.
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Papers
Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression.
Bing Lu,Howard J. Federoff +1 more
TL;DR: A glucocorticoid-inducible transcription unit was inserted into herpes simplex virus type 1 (HSV-1) amplicon vectors to determine if regulated expression can be achieved in cell lines and primary hepatocytes and the kinetics of h GH accumulation after induction and the dependence of hGH expression with respect to dexamethasone concentration were characterized.
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Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector.
TL;DR: The results indicate the feasibility of hepatic gene transfer with a defective HSV-1 vector and suggest that in vivo regulation of the HSV IE4/5 promoter was responsible for the short-term expression of lacZ, which should be overcome by the use of liver-specific promoters.
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Functional characterization of the rat GAP-43 promoter
TL;DR: Two polypurine tracts within the 5'-flanking DNA sequence of the GAP-43 gene adopt a non-duplex configuration in plasmids, and, when studied in the context of chromosomal integration, these regions have a stimulatory effect on transcription.
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Expression of Neurotrophic Genes from Herpes Simplex Virus Type 1 Vectors: Modifying Neuronal Phenotype
TL;DR: This chapter discusses methodologies used for one type of HSV-1 defective viral vector, the amplicon, a plasmid-based system of gene transfer that is effective for many cell types, including postmitotic neurons.
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Long non-coding RNAs: Modulators of phenotypic transformation in vascular smooth muscle cells
Bing Lu,Huiwen Liu,Shuwei Guo,Jie Zhang,Dongxu Li,Zhigang Chen,Fei Lin,Guoliang Zhao +7 more
TL;DR: The role of lncRNAs in regulating vascular smooth muscle cells in atherosclerosis, hypertension, aortic dissection, vascular restenosis, and aneurysms is summarized, providing new ideas for the diagnosis and treatment of vascular diseases.
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