Bing Hao

TL;DR: The authors found that absence of YetF or YdfS, both Duf421 domain-containing proteins and found only in wild-type (wt) B. subtilis spores with YetF more abundant, leads to decreased resistance to wet heat and agents that can damage spore core components.

TL;DR: This work reveals that TDP-43 is a critical governor of the transcriptional output from nuclear p65/NF-kB, which has paradoxical roles in barrier maintenance and also barrier compromising inflammatory responses, and suggests that disease specific loss in ECs contributes to BBB defects observed in the progression of AD, ALS and FTD.

TL;DR: Research reveals that endothelial TDP-43 depletion disrupts core blood-brain barrier pathways in neurodegenerative diseases, including Alzheimer's, ALS, and FTD, by reducing nuclear β-catenin and increasing NF-κB markers, leading to barrier breakdown.

TL;DR: In this article , structural and biochemical characterization of the neuronal RhoGEF Kalirin with Sec14 domain is presented, which adopts a closed conformation, sealing off the canonical ligand entry site, and instead employs a surface groove to bind a limited set of lysophospholipids.