Bing Han
University of Manchester
9 Papers
1 Citations
Bing Han is an academic researcher from University of Manchester. The author has contributed to research in topics: Congenital hyperinsulinism & Pancreas. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Bing Han include Boston Children's Hospital.
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Papers
Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation
S E Cross,S E Cross,R H Vaughan,R H Vaughan,A.J. Willcox,A.J. Willcox,A.J. McBride,A.J. McBride,Anju Abraham,Anju Abraham,Bing Han,J D Johnson,J D Johnson,Elisa Maillard,Elisa Maillard,P A Bateman,P A Bateman,Reshma Ramracheya,Patrik Rorsman,Karl E. Kadler,Mark J. Dunne,Stephen J. Hughes,Stephen J. Hughes,Paul Johnson,Paul Johnson +24 more
TL;DR: Islet function and survival may be compromised as a consequence of an incomplete islet BM, which has implications for islet survival and transplanted graft longevity.
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mTOR inhibitors for the treatment of severe congenital hyperinsulinism: perspectives on limited therapeutic success.
Marie Szymanowski,Maria Salomon Estebanez,Raja Padidela,Bing Han,Karolina Mosinska,Adam Stevens,Lena Damaj,Florence Pihan-Le Bars,Emilie Lascouts,Rachel Reynaud,Catherine Ferreira,Claire Bansept,Pascale de Lonlay,Pascale de Lonlay,Cécile Saint-Martin,Mark J. Dunne,Indraneel Banerjee,Jean-Baptiste Arnoux +17 more
TL;DR: In this article, an observational review of 10 severe hyperinsulinism patients treated with mTOR inhibitors, in France and the United Kingdom, with the intention of achieving glycemic control without pancreatectomy, was conducted.
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Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets.
Changhong Li,Changhong Li,Amanda M. Ackermann,Kara E. Boodhansingh,Tricia R. Bhatti,Chengyang Liu,Jonathan Schug,Nicolai M. Doliba,Bing Han,Karen E. Cosgrove,Indraneel Banerjee,Franz M. Matschinsky,Itzhak Nissim,Klaus H. Kaestner,Ali Naji,N. Scott Adzick,Mark J. Dunne,Charles A. Stanley,Charles A. Stanley,Diva D. De León,Diva D. De León +20 more
TL;DR: The findings demonstrate that the pathophysiology of KATPHI is complex, and they provide a framework for the identification of new potential therapeutic targets for this devastating condition.
Enhanced Islet Cell Nucleomegaly Defines Diffuse Congenital Hyperinsulinism in Infancy but Not Other Forms of the Disease.
Bing Han,Melanie Newbould,Gauri Batra,Edmund Cheesman,Ross J. Craigie,Zainab Mohamed,Zainab Mohamed,Lindsey Rigby,Raja Padidela,Mars Skae,Alexander A. Mironov,Tobias Starborg,Karl E. Kadler,Karen E. Cosgrove,Indraneel Banerjee,Mark J. Dunne +15 more
TL;DR: Increased incidence of nucleomegaly is pathognomonic for CHI-D, but these cells are nonproliferative, suggesting a novel role in the pathobiology of this condition.
Atypical Forms of Congenital Hyperinsulinism in Infancy Are Associated With Mosaic Patterns of Immature Islet Cells
Bing Han,Zainab Mohamed,Maria Salomon Estebanez,Ross J. Craigie,Melanie Newbould,Edmund Cheesman,Raja Padidela,Mars Skae,Matthew B. Johnson,Sarah E. Flanagan,Sian Ellard,Karen E. Cosgrove,Indraneel Banerjee,Mark J. Dunne +13 more
TL;DR: Marked increases in NKX2.2 expression combined with increased numbers of &dGr;‐cells strongly imply that an immature &dgr;‐cell profile contributed to the pathobiology of CHI‐A.