Bin Yang
4 Papers
25 Citations
Bin Yang is an academic researcher. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 3, co-authored 4 publications.
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Papers
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis
Ji-An Pan,Ji-An Pan,Yu Sun,Yu Sun,Ya Ping Jiang,Alex J. Bott,Alex J. Bott,Nadia Jaber,Zhixun Dou,Bin Yang,Juei Suei Chen,Joseph M. Catanzaro,Chunying Du,Wen-Xing Ding,Maria T. Diaz-Meco,Jorge Moscat,Keiko Ozato,Richard Z. Lin,Wei-Xing Zong,Wei-Xing Zong +19 more
TL;DR: It is shown that TRIM21 plays an essential role in redox regulation by directly interacting with SQSTM1/p62 and ubiquitylating p62 at lysine 7 (K7) via K63-linkage and abrogates p62 oligomerization and sequestration of proteins including Keap1, a negative regulator of antioxidant response.
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The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
Fang Wang,Ye Zhang,Jianliang Shen,Bin Yang,Weiwei Dai,Junrong Yan,Sara Maimouni,Heineken Queen Daguplo,Sara Coppola,Ying-Tang Gao,Yijun Wang,Zhi Du,Kesong Peng,Hui Liu,Qin Zhang,Fei Tang,Peng Wang,Shenglan Gao,Yongbo Wang,Wen-Xing Ding,Grace L. Guo,Fengmei Wang,Wei-Xing Zong +22 more
TL;DR: In this article, the role of TRIM21 in hepatocarcinogenesis was examined using publicly available data sets and 49 cases of hepatic tissue repair response and compensatory proliferation.
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Enhanced specificity of real-time PCR for measurement of hepatitis B virus cccDNA using restriction endonuclease and plasmid-safe ATP-dependent DNase and selective primers.
TL;DR: A modified method was developed using digestion with restriction endonucleases that do not recognize sites in the HBV DNA and plasmid-safe ATP-dependent DNase, and using a cccDNA-specific primer set in a real-time PCR reaction that has the potential for evaluating the efficacy of antiviral drugs.
26
The MTHFR C677T mutation is not a risk factor recognized for HBV-related HCC in a population with a high prevalence of this genetic marker.
Xiao-lei Jiao,Ying Luo,Bin Yang,Li Jing,Yayue Li,Chang-Zheng Liu,Xiang Jing,Feng-mei Wang,Yi-Jun Wang,Zhi Du,Ying-Tang Gao +10 more
TL;DR: The TT genotype and T allele of MTHFR C677T may confer a protective effect on disease progression to HCC in HBV-infected individuals, especially among male patients, in a population with a high prevalence of this genetic marker.