Bin Wei
Tongji University
4 Papers
9 Citations
Bin Wei is an academic researcher from Tongji University. The author has contributed to research in topics: Innate immune system & Biology. The author has an hindex of 2, co-authored 4 publications. Previous affiliations of Bin Wei include Shanghai University.
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Papers
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Xin Zhou,Weiyun Li,Shuang Wang,Panli Zhang,Qiong Wang,Jun Xiao,Chi Zhang,Xin Zheng,Xiaoyan Xu,Shengjie Xue,Lijian Hui,Hongbin Ji,Bin Wei,Bin Wei,Hongyan Wang +14 more
TL;DR: YAP in macrophages aggravates IBD, accompanied by the production of antimicrobial peptides and changes in gut microbiota, and this study suggests that fully understanding the multiple functions of YAP in different cell types is crucial for IBD therapy.
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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Jun Xiao,Weiyun Li,Xin Zheng,Linlin Qi,Hui Wang,Chi Zhang,Xiaopeng Wan,Yuxiao Zheng,Ruiyue Zhong,Xin Zhou,Yao Lu,Zhiqi Li,Ying Qiu,Chang Liu,Fang Zhang,Yanbo Zhang,Yanbo Zhang,Xiaoyan Xu,Xiaoyan Xu,Zhongzhou Yang,Hualan Chen,Qiwei Zhai,Bin Wei,Bin Wei,Hongyan Wang,Hongyan Wang +25 more
TL;DR: This work has shown that upon DNA and RNA viral infection, macrophages reduced 7-dehydrocholesterol reductase (DHCR7) expression and it was elucidated that viral infection or 7-DHC treatment enhanced AKT3 expression and activation.
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Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity.
Chi Zhang,Weiyun Li,Weiyun Li,Xiaobo Lei,Zhenfei Xie,Linlin Qi,Hui Wang,Xia Xiao,Jun Xiao,Yuxiao Zheng,Chen Dong,Xin Zheng,Shiyang Chen,JianFeng Chen,Bing Sun,Jun Qin,Qiwei Zhai,Jinsong Li,Bin Wei,Bin Wei,Jianwei Wang,Hongyan Wang +21 more
TL;DR: In this article, the lipid lysophosphatidic acid (LPA) concentrations are enhanced in patients upon HCV or SARS-CoV-2 infection, bu...
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LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumors and pathogens.
Chang Liu,Xiao Yan Xu,Lei Han,Lei Han,Xiaopeng Wan,Lingming Zheng,Chunyang Li,Chunyang Li,Zhaohui Liao,Jun Xiao,Ruiyue Zhong,Xin Zheng,Qiong A. Wang,Zonghai Li,Hualan Chen,Bin Wei,Bin Wei,Hongyan Wang +17 more
TL;DR: It is demonstrated thatLRCH1 directly binds LAT, reduces LAT phosphorylation and interaction with GRB2, and also promotes the endocytosis of LAT, which suggests LRCH1 as a potential translational target to improve T cell immunotherapy against infection and tumors.
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