Bin Liu
University of Groningen
15 Papers
11 Citations
Bin Liu is an academic researcher from University of Groningen. The author has contributed to research in topics: Genome editing & CRISPR. The author has an hindex of 7, co-authored 15 publications. Previous affiliations of Bin Liu include University of Massachusetts Medical School & Soochow University (Suzhou).
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Papers
Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing
Bin Liu,Siwei Chen,Anouk La Rose,Deng Chen,Fangyuan Cao,Martijn R. H. Zwinderman,Dominik Kiemel,Dominik Kiemel,Manon Aïssi,Frank J. Dekker,Hidde J. Haisma +10 more
TL;DR: It is demonstrated that attenuation of HDAC1, HDAC2 activity, but not other HDACs, enhances CRISPR/Cas9-mediated gene knockout frequencies by NHEJ as well as gene knock-in by HDR, and inhibition ofHDAC3 decreases gene editing frequencies.
Histone Deacetylase Inhibitors Sensitize TRAIL-Induced Apoptosis in Colon Cancer Cells
TL;DR: Combined treatment of RGFP966 with TRAIL variants (rhTRAIL 4C7/DHER) increases apoptosis on 3D tumor spheroid models and is the first to report that using RGFP 966 or PCI34051 in combination with rhTRAil 4C 7 or DHER represents an effective cancer therapy.
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A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL
TL;DR: It is found that downregulation of EP300 or CREBBP enhances apoptosis upon TRAIL stimulation in non-small-cell lung cancer (NSCLC) cells, and the combination of A485 and TRAIL synergistically increases cell death and inhibits long-term cell proliferation.
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CRISPR/Cas9 for overcoming drug resistance in solid tumors
TL;DR: The review findings revealed the importance of CRISPR/Cas9 system in understanding drug resistance mechanisms and identification of resistance-related genes such as PBRM1, SLFN11 and ATPE1 in different cancers.
CRISPR/Cas: A Faster and More Efficient Gene Editing System.
Bin Liu,Huifen Xu,Jiangfang Miao,Andy K. Zhang,Xiaojin Kou,Wen Li,Lin Zhou,Hong-Guang Xie,Pierre Sirois,Kai Li +9 more
TL;DR: This review discusses the discovery of CRISPR, the development of theCRISPR/Cas system, and its applications as a new gene editing system.
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