7 Papers
Bin Li is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Autophagy & ATG5. The author has an hindex of 7, co-authored 7 publications.
Chat about Author
Papers
Transcription factor EB is involved in autophagy-mediated chemoresistance to doxorubicin in human cancer cells.
TL;DR: It is demonstrated that TFEB-mediated autophagy activation decreases the sensitivity of cancer cells to doxorubicin.
Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer.
TL;DR: Bufalin can be used as a new promising anticancer drug for gallbladder cancer patients who are resistant to traditional chemotherapy and enhanced the chemotherapeutic sensitivity and reduced the metastasis of gallbladders carcinoma.
Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway.
Zhong Wang,Qiang Chen,Bin Li,Jiaming Xie,Xiaodong Yang,Kui Zhao,Yong Wu,Zhenyu Ye,Zhengrong Chen,Zheng-Hong Qin,Chungen Xing +10 more
TL;DR: It is demonstrated that p62 regulates ATM/γH2AX pathway-mediated escin-induced DNA damage and apoptosis, and p62 knockdown combined with the ATM inhibitor KU55933 augmented escIn-inducedDNA damage and further increased esc in-induced apoptosis.
Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy
Bin Li,Guoliang Wu,Wei Dai,Gang Wang,Hao-yuan Su,Xue-ping Shen,Rui Zhan,Jiaming Xie,Zhong Wang,Zheng-Hong Qin,Quan-gen Gao,Gen-hai Shen +11 more
TL;DR: It is demonstrated that aescin dose-dependently induced apoptosis and activated mammalian target of rapamycin (mTOR)-independent autophagy in human hepatocellular carcinoma HepG2 cells and colon carcinoma HCT 116 cells, and combined administration of the antioxidants or autophagic inhibitors with aescIn might be a potential strategy to enhance the anticancer effect of aesc in vivo.
TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway
Hong-Pei Yu,Jiaming Xie,Bin Li,Yi-Hui Sun,Quan-Geng Gao,Zhi-Hui Ding,Hao-Rong Wu,Zheng-Hong Qin +7 more
TL;DR: The Cdk5-AMT signal pathway involved in regulation of DDR by TIGar defines a new role of TIGAR in cancer cell survival and it suggests that TigAR may be a therapeutic target for cancers.