12 Papers
53 Citations
Bin Li is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Cell growth & Cytotoxicity. The author has an hindex of 6, co-authored 12 publications.
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Papers
Gold nanoparticles delivered miR-375 for treatment of hepatocellular carcinoma
Huiying Xue,Yong Liu,Jia-Zhi Liao,Ju-Sheng Lin,Bin Li,Weigang Yuan,Robert J. Lee,Lei Li,Chuanrui Xu,Xing-Xing He +9 more
TL;DR: The findings indicate that AuNPs is a reliable strategy to deliver miR-375 into HCC cells and tissue, and that AuNP-miR- 375 has the potential in the clinic for treatment of unresectable HCC.
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Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis.
Bin Li,Yuyuan Chen,Fei Wang,Jun Guo,Wen Fu,Min Li,Qichang Zheng,Yong Liu,Lingling Fan,Lei Li,Chuanrui Xu +10 more
TL;DR: The findings elucidate the molecular mechanism underlying hepatic Bmi1-driven carcinogenesis and highlight the importance of TGFβ2 as a tumour suppressor in HCC development.
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Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Hua Wu,Yuyuan Chen,Bin Li,Chun Li,Jun Guo,Jia You,Xian Hu,Dong Kuang,Shibo Qi,Pin Liu,Lei Li,Chuanrui Xu +11 more
TL;DR: Both ROCK1 and ROCK2 are required for HCC cell division and growth and targeting ROCK1 or ROCK2 rather than both can serve as a potential approach for H CC treatment and may reduce the side effects.
17
Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin.
Cheng-Jie Yang,Bin Li,Zhi-Jun Zhang,Gao Jianmei,Mei-Juan Wang,Xiao-Bo Zhao,Zi-Long Song,Ying-Qian Liu,Ying-Qian Liu,Hu Li,Yuyuan Chen,Kuo Hsiung Lee,Susan L. Morris-Natschke,Chuanrui Xu +13 more
TL;DR: Results indicated that compound c20 could be a potential anti-cancer candidate for further clinical trial because it possesses remarkable in vitro cytotoxic activity and is more potent than topotecan.
16
A novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo.
Yifei Huang,Tan Yang,Wendian Zhang,Yao Lu,Peng Ye,Guang Yang,Bin Li,Shibo Qi,Yong Liu,Xing-Xing He,Robert J. Lee,Chuanrui Xu,Guangya Xiang +12 more
TL;DR: F-CONH-PEG-NH-Chol represents a physically stable and effective ligand for delivering folate receptor-targeted liposomes, with prolonged circulation time and efficient tissue distribution, as well as higher efficacy and less cardiac toxicity.
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