Bin Li
Pfizer
8 Papers
64 Citations
Bin Li is an academic researcher from Pfizer. The author has contributed to research in topics: Target protein & Ligand (biochemistry). The author has an hindex of 6, co-authored 6 publications.
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Papers
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Yuefen Zhou,Stephen E. Webber,Douglas E. Murphy,Lian-Sheng Li,Peter S. Dragovich,Tran Chinh Viet,Zhongxiang Sun,Frank Ruebsam,Amit M. Shah,Mei Tsan,Richard E. Showalter,Rupal Patel,Bin Li,Qiang Zhao,Qing Han,Thomas Hermann,Charles R. Kissinger,Laurie A. LeBrun,Maria V. Sergeeva,Leo Kirkovsky +19 more
TL;DR: 5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase and the synthesis, structure-activity relationships, metabolic stability, and structure-based design approach for this new class of compounds are discussed.
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Patent
Methods of screening for ligands of target molecules
Hakim Djaballah,Scott Rongey,Rupal Patel,Mei Mei Wang,Joseph Coyle,Bin Li,Stephen Worland +6 more
- 13 Jun 2002
TL;DR: In this article, the degree of unfolding of a target molecule is determined by binding of a specific binding member specific for the unfolded form of the target molecule that is coupled to a fluorophore that can participate in FRET.
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Identification of ligand binding by protein stabilization: comparison of ATLAS with biophysical and enzymatic methods.
Peggy A. Thompson,Shaohui Wang,Lindsay J. Howett,Mei-Mei Wang,Rupal Patel,April Averill,Richard E. Showalter,Bin Li,James R. Appleman +8 more
TL;DR: Comparison of the ATLAS 50% effective concentration with other biophysical and biochemical methods offered insight into optimizing ATLAS assay conditions to maximize sensitivity to compound binding and protein stabilization.
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ATLAS--a high-throughput affinity-based screening technology for soluble proteins: technology application using p38 MAP kinase.
Rupal Patel,Laurie A. LeBrun,Shaohui Wang,Lindsay J. Howett,Peggy A. Thompson,James R. Appleman,Bin Li +6 more
TL;DR: A general affinity-based screening assay for discovery of lead compounds binding to potential protein drug targets that is based upon protein thermal unfolding and aggregation is described.
11
SCAN--a high-throughput assay for detecting small molecule binding to RNA targets.
TL;DR: A correlation between SCAN™ EC50 and KD values is reported suggesting the ability to use the assay for compound optimization, and a high-throughput screen of the entire compound library resulted in the identification of small molecule ligands that bind to Loop IIId.
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