Bin Chen
University of Michigan
20 Papers
192 Citations
Bin Chen is an academic researcher from University of Michigan. The author has contributed to research in topics: Allylic rearrangement & Chemistry. The author has an hindex of 8, co-authored 19 publications. Previous affiliations of Bin Chen include Massachusetts Institute of Technology & Bristol-Myers Squibb.
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Papers
Succinct Synthesis of β-Amino Acids via Chiral Isoxazolines
TL;DR: A straightforward method employing chiral isoxazolines as key intermediates to access five different β-amino acid structural types with excellent selectivity is presented and is expected to facilitate future studies of the structure and function of this important class of molecules.
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Succinct Synthesis of β‐Amino Acids via Chiral Isoxazolines.
TL;DR: In this paper, a straightforward method employing chiral isoxazolines as key intermediates to access five different β-amino acid structural types with excellent selectivity was presented.
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Patent
Inhibitors of indoleamine 2,3-dioxygenase (ido)
James Aaron Balog,Audris Huang,Bin Chen,Libing Chen,Steven P. Seitz,Hart Amy C,Jay A. Markwalder +6 more
- 12 Mar 2014
TL;DR: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention as discussed by the authors.
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Stereoselective intermolecular formal [3+3] cycloaddition reaction of cyclic enamines and enones.
Mohammad Movassaghi,Bin Chen +1 more
TL;DR: A new highly diastereoselective reaction involving cyclic enamines and enones that provides rapid access to tricyclic imino alcohols and derivatives thereof and discusses the findings in the development of catalytic and asymmetric variants of this formal [3+3]-cycloaddition reaction.
A phosphorimidate rearrangement for the facile and selective preparation of allylic amines.
Bin Chen,Anna K. Mapp +1 more
TL;DR: Allylic phosphorimidates, readily prepared from the combination of an allylic alcohol, an azide, and a chlorophosphite, undergo [3,3]-rearrangement under thermal conditions to provide single isomers of allies phosphoramidates, providing an attractive and versatile procedure for the preparation of key synthetic intermediates, allylic amines.
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