Biena Mathew
Goethe University Frankfurt
5 Papers
51 Citations
Biena Mathew is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Inner cell mass & Cell fate determination. The author has an hindex of 4, co-authored 5 publications.
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Papers
Robust and automated three-dimensional segmentation of densely packed cell nuclei in different biological specimens with Lines-of-Sight decomposition
Biena Mathew,Alexander Schmitz,Silvia Muñoz-Descalzo,Nariman Ansari,Francesco Pampaloni,Ernst H. K. Stelzer,Sabine C. Fischer +6 more
TL;DR: This work has developed a novel and fully automated three-dimensional cell nuclei segmentation method incorporating LoS decomposition, which showed superior performance compared to state-of-the-art methods, performing accurately for a variety of test images.
Mouse ICM Organoids Reveal Three-Dimensional Cell Fate Clustering.
Biena Mathew,Silvia Muñoz-Descalzo,Elena Corujo-Simon,Christian Schröter,Ernst H. K. Stelzer,Sabine C. Fischer +5 more
TL;DR: The investigation of the spatial distributions both in vivo and in vitro dissects the contributions of the different parts of the embryo to cell fate specifications, which can be extended to other mammalian organisms and thus creates a powerful approach to study embryogenesis.
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Cell fate clusters in ICM organoids arise from cell fate heredity and division: a modelling approach
Tim Liebisch,Armin Drusko,Biena Mathew,Ernst H. K. Stelzer,Sabine C. Fischer,Franziska Matthäus +5 more
TL;DR: In this paper, an agent-based model accounting for mechanical cell-cell interaction and cell fate heredity was developed to quantify the influence of cell proliferation on the observed cell lineage type clustering.
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Cell Fate Clusters in ICM Organoids Arise from Cell Fate Heredity & Division – a Modelling Approach
Tim Liebisch,Armin Drusko,Biena Mathew,Ernst H. K. Stelzer,Sabine C. Fischer,Franziska Matthäus +5 more
TL;DR: The model supports the hypothesis that initial cell fate acquisition is a stochastically driven process, taking place in the early development of inner cell mass organoids, and shows that the observed neighbourhood structures can emerge due to cell fate heredity during cell division and allows the inference for a time point for the cell fate decision.
E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity
TL;DR: The phases of spheroid formation resemble different stages of cell contact formation, which facilitates studying the temporal contribution of molecules in this process.