Bettina Ebert
University of Kiel
12 Papers
51 Citations
Bettina Ebert is an academic researcher from University of Kiel. The author has contributed to research in topics: Reductase & Carbonyl Reductase. The author has an hindex of 8, co-authored 12 publications.
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Papers
Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29
TL;DR: Treatment with proteasome inhibitors increased the expression of several AKRs as well as of MRP2, and it remains to be investigated whether this enzyme induction may contribute to enhanced cell survival and thereby supporting the phenomenon of multidrug resistance upon cancer chemotherapy.
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Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells.
TL;DR: It is shown for the first time that human CBR3 is a new member of the Nrf2 gene battery, and the regulation of its expression is regulated via NRF2, a key regulator in response to oxidative stress.
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Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1.
TL;DR: Inhibition of CBR1 may increase the efficacy of daunorubicin in cancer tissue and simultaneously decrease its cardiotoxicity, suggesting a beneficial effect in the co-treatment of anthracycline anti-tumor drugs together with curcumin.
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Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3.
Claudia A. Staab,Tereza Hartmanová,Tereza Hartmanová,Yasser El-Hawari,Bettina Ebert,Michael Kisiela,Vladimír Wsól,Hans-Jörg Martin,Edmund Maser +8 more
TL;DR: The results clearly argue for a physiological role of CBR1, but not for CBR3, in GSNO reduction and thus ultimately in regulation of NO signaling.
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Analysis of alternative promoter usage in expression of HSD11B1 including the development of a transcript-specific quantitative real-time PCR method.
Claudia A. Staab,Jochen Stegk,Sierk Haenisch,Elisabeth Neiss,Katrin Köbsch,Bettina Ebert,Ingolf Cascorbi,Edmund Maser +7 more
TL;DR: The results provide the first evidence for tissue- and differentiation state-specific promoter usage in expression of human HSD11B1.
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