Beth Browning
Biogen Idec
15 Papers
294 Citations
Beth Browning is an academic researcher from Biogen Idec. The author has contributed to research in topics: Cytokine TWEAK & Integrin. The author has an hindex of 10, co-authored 14 publications.
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Papers
TWEAK induces liver progenitor cell proliferation
Aniela Jakubowski,Christine Ambrose,Michael Parr,John Lincecum,Monica Z. Wang,Timothy S. Zheng,Beth Browning,Jennifer S. Michaelson,Manfred Baestcher,Bruce Wang,D. Montgomery Bissell,Linda C. Burkly +11 more
TL;DR: Evidence is presented that a TNF family member called TWEAK (TNF-like weak inducer of apoptosis) stimulates oval cell proliferation in mouse liver through its receptor Fn14, and it is concluded that T WEAK has a selective mitogenic effect for liver oval cells that distinguishes it from other previously described growth factors.
TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease
Bhanu P. Pappu,Anna Borodovsky,Timothy S. Zheng,Xuexian O. Yang,Ping Wu,Xingwen Dong,Shawn Weng,Beth Browning,Martin L. Scott,Li Ma,Lihe Su,Qiang Tian,Pascal Schneider,Richard A. Flavell,Chen Dong,Linda C. Burkly +15 more
TL;DR: It is demonstrated that during EAE disease progression, TL1A was required for the optimal differentiation as well as effector function of Th17 cells, and animals displayed decreased clinical severity in experimental autoimmune encephalomyelitis (EAE).
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration
Mahasweta Girgenrath,Shawn Weng,Christine A. Kostek,Beth Browning,Monica Wang,Sharron A.N. Brown,Jeffrey A. Winkles,Jennifer S. Michaelson,Norm Allaire,Pascal Schneider,Martin L. Scott,Yen-Ming Hsu,Hideo Yagita,Richard A. Flavell,Jeffrey Boone Miller,Linda C. Burkly,Timothy S. Zheng +16 more
TL;DR: The results indicate that the TWEAK/Fn14 pathway is a novel regulator of skeletal muscle precursor cells and illustrate an important mechanism by which inflammatory cytokines influence tissue regeneration and repair.
Proinflammatory Effects of Tweak/Fn14 Interactions in Glomerular Mesangial Cells
Sean Campbell,Linda C. Burkly,Hua Xin Gao,Joan W. Berman,Lihe Su,Beth Browning,Timothy S. Zheng,Lena Schiffer,Jennifer S. Michaelson,Chaim Putterman +9 more
TL;DR: It is found that murine mesangial cells express cell surface TWEAK receptor and induced levels of chemokines were comparable to those found following mesangia cell exposure to potent proinflammatory stimuli such as TNF-α + IL-1β.
TWEAK Is a Novel Arthritogenic Mediator
Stuart J. Perper,Beth Browning,Linda C. Burkly,Shawn Weng,Cindy Gao,Keith Giza,Lihe Su,Leticia Tarilonte,Thomas Crowell,Luis Rajman,Laura Runkel,Martin L. Scott,Gerald J. Atkins,David M. Findlay,Timothy S. Zheng,Henry Hess +15 more
TL;DR: It is demonstrated that TWEAK induced the production of matrix metalloproteases in human chondrocytes and potently inhibited chondrogenesis and osteogenesis using in vitro models, and provided evidence for a novel cytokine pathway that contributes to joint tissue inflammation, angiogenesis, and damage.
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