Berthold Lausecker
Hoffmann-La Roche
18 Papers
156 Citations
Berthold Lausecker is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Bioanalysis & Mass spectrometry. The author has an hindex of 13, co-authored 18 publications.
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Papers
Metabolic profiles of minimally absorbed orlistat in obese/overweight volunteers
Jianguo Zhi,Angela T. Melia,Christoph Funk,Antoinette Viger-Chougnet,Gérard Hopfgartner,Berthold Lausecker,Ka Wang,Jeffrey S. Fulton,Lana Gabriel,Thomas E. Mulligan +9 more
TL;DR: The disposition of orlistat appears to be similar between normal and obese/overweight subjects.
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Incurred sample reproducibility: views and recommendations by the European Bioanalysis Forum
Philip Timmerman,Silke Luedtke,Peter van Amsterdam,Margarete Brudny-Kloeppel,Berthold Lausecker,Stephanie Fischmann,Susanne Globig,Carl Johan Sennbro,Josep Maria Jansat,Hans Mulder,Elizabeth Thomas,Magnus Knutsson,Dirk Kasel,Stephen White,Morten A. Kall,Nathalie Mokrzycki-Issartel,Achim Freisleben,Fernando Romero,Michael P. Andersen,Norbert Knebel,Marcel de Zwart,Sirpa Laakso,Richard Hucker,Dietmar Schmidt,Ben Gordon,Richard Abbott,Pierre Boulanger +26 more
TL;DR: The ultimate goal of the EBF recommendation is to ensure that bioanalytical methods can provide accurate and reproducible concentration data for pharmacokinetic and/or toxicokinetic evaluation, without any compromise, while safeguarding the optimal use of laboratory resources.
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Workshop/Conference Report on EMA Draft Guideline on Validation of Bioanalytical Methods
Henning Blume,E. Brendel,Margarete Brudny-Klöppel,Sylvia Grebe,Berthold Lausecker,Gabriele Rohde,Christoph Siethoff +6 more
TL;DR: This is a summary report of the workshop on the EMA Draft Guideline on Validation of Bioanalytical Methods held April 15-16th 2010 in Brussels and jointly organised by the European Bioanalysis Forum and the European Federation for Pharmaceutical Sciences.
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Simultaneous determination of bosentan and its three major metabolites in various biological matrices and species using narrow bore liquid chromatography with ion spray tandem mass spectrometric detection.
TL;DR: An analytical method was developed for the determination of bosentan and its three main metabolites in various matrices and species with focus on robustness, which proved to be robust, sensitive, and selective during the analysis of several thousand samples.
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A novel double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C]tofogliflozin after oral administration and concomitant intravenous microdose administration of [13C]tofogliflozin in humans.
TL;DR: The utility of the double-tracer approach to provide essential pharmacokinetic data and excretion data for drug-related material in one study at the same dosing occasion is demonstrated.
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