Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities

Mammalian hair growth is reduced by applying to the skin a composition including an inhibitor of 5-lipoxygenase.

Inhibition of hair growth

The invention relates to compositions, methods, apparatus, and kits for alleviating or preventing vasoconstriction or vasospasm in a mammal. The compositions, methods, apparatus, and kits are also useful for alleviating or preventing ischemic tissue damage resulting from ischemia associated with cerebral vasoconstriction which follows aneurysmal subarachnoid hemorrhage, with embolic stroke, with coronary artery obstruction, and with other conditions. These compositions, methods, apparatus, and kits generally relate to adventitial (i.e. extra-luminal) administration of a nitric oxide donor compound to a blood vessel in a mammal.

Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal

Polymethine dyes and ultraviolet absorbers are disclosed containing a basic electron donating terminal nucleus and an acidic electron accepting terminal nucleus satisfying the formula: ##STR1## where Ar is independently in each occurrence an aromatic group and D is an oxy or amino group. These polymethines are useful in imaging materials.

Novel polymethine dyes and UV absorbers and imaging materials for their use

Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula ##STR1## E.G., N-methyl-N[2-(N-pyrrolidinyl)cyclohexyl[3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.

Analgesic n-(2-aminocycloaliphatic)benzamides

1-aminoalkyl 2-aryl indanes and tetrahydronaphthalenes

N-amino-loweralkylene-benzo-lactams

2-substituted aminomethylcyclooctyl amides of alkyl substituted acetic acid

5, 11-dihydrodibenz and 5, 11-pyridobenz-[b, e] [1, 4]oxazepine-5-carboxylic acid amides and derivatives

Central nervous system active compounds

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