Bernhard Schöpf
University of Zurich
4 Papers
59 Citations
Bernhard Schöpf is an academic researcher from University of Zurich. The author has contributed to research in topics: Targeted drug delivery & Nanoparticle. The author has an hindex of 4, co-authored 4 publications.
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Papers
Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system
TL;DR: The characteristics and applications of SPION in the biomedical sector are introduced and discussed, and superparamagnetic nanoparticles based on a core consisting of iron oxides that can be targeted through external magnets are discussed.
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Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep
Katja Schulze,Annette Koch,Bernhard Schöpf,A. Petri,Benedikt Steitz,Mathieu Chastellain,M. Hofmann,Heinrich Hofmann,Brigitte von Rechenberg +8 more
TL;DR: A superparamagnetic iron oxide nanoparticle, coated with polyvinyl alcohol, and its fluorescently functionalized analogue (amino-PVA-Cy3.5-SPION) were compared in vivo as proof of principle for future use in magnetic drug targeting in inflammatory joint diseases.
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Methodology description for detection of cellular uptake of PVA coated superparamagnetic iron oxide nanoparticles (SPION) in synovial cells of sheep
Bernhard Schöpf,Tobias Neuberger,Katja Schulze,A. Petri,Matthieu Chastellain,Margarete Hofmann,Heinrich Hofmann,Brigitte von Rechenberg +7 more
TL;DR: The detection of superparamagnetic iron oxide nanoparticles (SPION) in synoviocytes is reported and particles were well tolerated by the synoviocyte and were easily detected using the Turnbulls and Prussian blue reactions.
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Systemic distribution and elimination of plain and with Cy3.5 functionalized poly(vinyl alcohol) coated superparamagnetic maghemite nanoparticles after intraarticular injection in sheep in vivo.
Daniel Hellstern,Katja Schulze,Bernhard Schöpf,Alke Petri-Fink,Benedikt Steitz,Sarah W. Kamau,Monika Hilbe,Sabine Koch-Schneidemann,Lloyd Vaughan,Michael O. Hottiger,M. Hofmann,Heinrich Hofmann,Brigitte von Rechenberg +12 more
TL;DR: The results indicated that the iron component of the SPION is possible to be incorporated into the physiologic iron metabolism after reabsorption in the proximal tubule system of the kidney and that concentration levels of Cy3.5 are too low to be detected throughout the body.
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