Bernhard Ryffel
École Polytechnique Fédérale de Lausanne
8 Papers
116 Citations
Bernhard Ryffel is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Interferon gamma & Receptor tyrosine kinase. The author has an hindex of 7, co-authored 8 publications.
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Papers
Role of interferon-gamma in contact hypersensitivity assessed in interferon-gamma receptor-deficient mice.
TL;DR: It is concluded that oxazolone- and TNCB-induced contact hypersensitivity is partially dependent on a functional IFN gamma system and reduced cellular infiltrates are likely due to a reduced upregulation of ICAM-1 and class I antigen expression in IFN Gamma R-/- mice.
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Growth inhibition of human colorectal-carcinoma cells by interleukin-4 and expression of functional interleukin-4 receptors.
Harald Lahm,B. Schnyder,Josiane Wyniger,Zita Borbenyi,Aysim Yilmaz,Bruce D. Car,Jürgen Fischer,Jean-Claude Givel,Bernhard Ryffel +8 more
TL;DR: An important role is attributed for IL‐4 as a negative regulator of colorectal‐carcinoma cell growth, thus indicating a possible avenue for intervention in this disease.
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Cyclosporin binding proteins: Identification, distribution, function and relation to FK binding proteins
TL;DR: In this article, the authors reviewed the cellular cyclosporin binding proteins, especially the cyclophilin (CPH) family and the related IX-binding proteins, and is restricted to mammalian proteins.
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Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for cyclosporine.
Bernhard Ryffel,Gaetane Woerly,Carmen Rodriguez,Brian M. J. Foxwell +3 more
- 01 Jan 1991
TL;DR: It is suggested that cyclosporine reverses the MDR phenotype by binding directly to P-glycoprotein and that this binding is not dependent on the immunosuppressive potential of the cyclospora derivative.
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Growth inhibition signalled through the interleukin-4/interleukin-13 receptor complex is associated with tyrosine phosphorylation of insulin receptor substrate-1.
TL;DR: The present study demonstrates the involvement of a novel chain other than the gama-chain in the receptor complexes of IL-4 and IL-13 and and post-receptor tyrosine phosphorylation of IRS-1, suggesting a novel mechanism of tumour growth control.