Bernhard Bielesz
Albert Einstein College of Medicine
6 Papers
28 Citations
Bernhard Bielesz is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Notch signaling pathway & Internal medicine. The author has an hindex of 3, co-authored 4 publications.
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Papers
The Notch pathway in podocytes plays a role in the development of glomerular disease
Thiruvur Niranjan,Bernhard Bielesz,Antje Gruenwald,Manish P. Ponda,Jeffrey B. Kopp,David B. Thomas,Katalin Susztak +6 more
TL;DR: Observations suggest that Notch activation in mature podocytes is a new mechanism in the pathogenesis of glomerular disease and thus could represent a new therapeutic target.
429
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
Bernhard Bielesz,Yasemin Sirin,Yasemin Sirin,Han Si,Thiruvur Niranjan,Antje Gruenwald,Seon-Ho Ahn,Hideki Kato,James Pullman,Manfred Gessler,Volker H. Haase,Katalin Susztak +11 more
TL;DR: It is established that epithelial injury and Notch signaling play key roles in fibrosis development and indicate that Notch blockade may be a therapeutic strategy to reduce fibrosis and ESRD development.
Patent
Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease
Katalin Susztak,Bernhard Bielesz,Thiruvur Niranjan +2 more
- 04 Sep 2008
TL;DR: In this article, methods for treating and preventing renal disease in a subject by administering a gamma secretase inhibitor or a Notch pathway inhibitor to the subject were described. But they did not discuss the effects of these drugs on the renal function.
27
Secondary calciprotein particle size is associated with patient mortality in peripheral artery disease.
TL;DR: In this article , the hydrodynamic radius (Rh) of CPP-II was measured by using dynamic light scattering in a cohort of 281 peripheral artery disease (PAD) patients.
3
Patent
Utilisation d'inhibiteurs de gamma secrétase et inhibiteurs de la voie notch pour le traitement et la prévention d'une maladie rénale
Katalin Susztak,Bernhard Bielesz,Thiruvur Niranjan +2 more
- 04 Sep 2008
TL;DR: In this article, the presente invention concerne des procedes destines au traitement et a la prevention d'une maladie renale chez un sujet par l'administration d'un inhibiteur de gamma secretase ou d'una voie notch au sujet.