Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1562&context=patents

Immunostimulatory nucleic acid molecules

Methods and apparatus are provided for selective surgical removal of tissue, e.g., for enlargement of diseased spinal structures, such as impinged lateral recesses and pathologically narrowed neural foramen. In some embodiments, a surgical tissue removal device includes a flexible elongate body that is adapted to conform with the target anatomy and a guidewire connector at the distal end region of the flexible elongate body configured to removably connect to the end of a guidewire so that the guidewire and flexible elongate body can be pulled distally. The body may have at least one blade edge, and the flexible elongate body may be a thin, flat, ribbon shaped flexible body that comprises a profile having a width that is substantially greater than a height.

Devices and methods for tissue access

Double-sided stretchable adhesive tapes are described for use in conventional applications, particularly including the mounting or joining of an object to another surface. An improvement lies within the ability to control the timing of the debonding of both surfaces so that one adhesive surface releases before the other. The earlier release can be either on the object side or the surface side, depending on the desired effect. The present invention is applicable to all stretchable tape constructions including the use of plastic backing materials and/or elastic backing materials and allows such an object to be removed without risking substantial snap-back of the adhesive tape or catapulting of the object. The aforementioned advantages can be achieved by a double-sided adhesive tape having a stretchable backing layer, plastic or elastic, and having a lower-adhesion or non-adhesive portion of one adhesive surface, so that a corresponding greater adhesion adhesive portion of the other side remains more aggressively adhered to a surface during stretch removal while the portion of the one adhesive surface is less aggressively adhered or completely released from its surface. A non-adhesive portion may be adhesive-free, or may be an adhesive layer portion which is rendered non-adhesive. A lower-adhesion portion may comprise a low adhesion material, i.e., a weaker adhesive, or may be rendered lower in adhesion by a treatment or coating.

Removable adhesive tape with controlled sequential release

A stretch releasing pressure sensitive adhesive tape includes a silicone pressure sensitive adhesive composition that exhibits a 180° peel strength on a glass substrate at 98 % relative humidity of at least about 5.47 N/dm and a non-tacky tab. A stretch releasing pressure sensitive adhesive tape includes a pressure sensitive adhesive composition having a modulus at 1 radian/second and -17 °C of no greater than about 1 x 107 Pa and a non-tacky tab.

Stretch releasing pressure sensitive adhesive tapes and articles

An article support adapted for adhering to a substrate is described. The article support preferably includes a base member, a stretch release adhesive tape adhered to that base member, and some mechanism for gripping the stretch release adhesive tape. These items are arranged so that when the base member is adhered to the substrate by the stretch release adhesive tape, the base member can be removed by pulling on the gripping means at an acute angle from the surface of the substrate. Gripping means which resist disassociation from the stretch release adhesive tape during the removal of the base from the substrate are disclosed, including handle types. The base member can be generic, suitable for attaching various types of support members via, for example, complimentary dovetail slides. In such cases, provision such as a latch can be made to temporarily lock the support member to the base member. The article support can be provided so that when the support member is removed from the base member, the gripping mechanism engages the support member to automatically stretch the tape and remove the base member from the substrate.

Article support using stretch releasing adhesives

Adhesive film strip for a temporary bond which can be detached without residue and without damage by pulling in the direction of the bond plane, having a layer structure comprising an elastic backing layer which is provided on one or both sides with an adhesive layer, characterized in that both the backing layer and the adhesive layer(s) comprise styrene block copolymers as base polymers, blended with tackifier resins which are compatible with the elastomer block of the styrene block copolymers used.

Adhesive film strip

Wiederablösbarer, selbstklebender Haken

Use of a prior-cleaning cloth for an adhesive bond brought about by means of an adhesive film which is rereleasable without damage by pulling in the direction of the bond plane and which has an adhesive composition based on polymers and/or copolymers of synthetic rubber and/or natural rubber, characterized in that the substrate to be bonded is rubbed with a prior-cleaning cloth of this kind which is impregnated with a moisture-reactive organosilane, the organosilane being dissolved in a solvent or solvent mixture and being present therein in a concentration of 0.1-3% by weight, whereupon, following a waiting time of a few minutes, the adhesive film is pressed onto the treated area and then an article, hook or the like is bonded to the other side of the adhesive film, or else in that, after a waiting time of a few minutes, the adhesive film is pressed onto the treated area, an article, hook or the like already being located in bonded-on form on the reverse of the adhesive film.

Using a cleaning cloth impregnated with coupling agent for adhesive films

Redetachable, self-adhesive hook or similar fixing device, characterized by a strip (1) of an adhesive film for reseparable bonding based on a thermoplastic rubber and tackifying resins, wherein the adhesive film has high elasticity and low plasticity and wherein the adhesion is lower than the cohesion, the adhesive power largely disappears on extension of the film, the ratio of the peel strength to the tear load is at least 1:1.5, and wherein an adhesive bond produced with this can be separated by pulling on the adhesive film in the direction of the adhesion plane, wherein one end of the strip (1) is provided on both sides with a covering (4), which at the same time serves as a tab for pulling, wherein at least the covering (4) located on the front side is opaque to UV and wherein the front side of the strip (1) carries, except for in the region of the covering (4), a baseplate (3) having a peg-shaped extension (2) pointing forwards, and the reverse of the strip (1) is covered with a release paper or a release film (5) which has a tab (6) in the region of the covering (4).

Redetachable, self-adhesive hook

Polyurethane-based pressure-sensitive adhesive, characterized in that the polyurethane is composed of the following starting materials which are reacted catalytically with one another in the stated proportions: a) at least one aliphatic or alicyclic polyisocyanate having a functionality of in each case less than or equal to three, b) a combination of at least one polypropylene glycol diol and at least one polypropylene glycol triol, the ratio of the number of hydroxyl groups in the diol component to the number of hydroxyl groups in the triol component being less than 10, preferably between 0.2 and 5, additionally the ratio of the number of isocyanate groups to the total number of hydroxyl groups being between 0.8 and 1.15, preferably between 0.95 and 1.05, more preferably between 1.0 and 1.05, the catalyst for the reaction to the polyurethane consisting of or comprising a bismuth carboxylate or bismuth carboxylate derivative, and the diols and triols alternatively being selected and combined in each case as follows: diols having a molecular weight of less than or equal to 1000 are combined with triols whose molecular weight is greater than or equal to 1000, preferably greater than or equal to 3000, diols having a molecular weight of greater than 1000 are combined with triols whose molecular weight is less than 1000.

Polyurethane PSA for sensitive surfaces

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