Bérangère Bertin
French Institute of Health and Medical Research
7 Papers
1 Citations
Bérangère Bertin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Adeno-associated virus & Biology. The author has an hindex of 3, co-authored 4 publications.
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Papers
Capsid-specific removal of circulating antibodies to adeno-associated virus vectors
Bérangère Bertin,Philippe Veron,Christian Leborgne,Jack-Yves Deschamps,Sophie Moullec,Yves Fromes,Fanny Collaud,Sylvie Boutin,Virginie Latournerie,Laetitia van Wittenberghe,Benoit Delache,Roger Le Grand,Nathalie Dereuddre-Bosquet,Olivier Benveniste,Philippe Moullier,Carole Masurier,Otto Wilhelm Merten,Federico Mingozzi +17 more
TL;DR: An AAV-specific plasmapheresis column was developed which was shown to efficiently and selectively deplete anti-AAV antibodies without depleting the total immunoglobulin pool from plasma, providing proof-of-concept of a method for the A AV-specific depletion of neutralizing antibodies in the setting of in vivo gene transfer.
Origins of truncated supplementary capsid proteins in rAAV8 vectors produced with the baculovirus system
Lionel Galibert,Adrien Savy,Yohann Dickx,Delphine Bonnin,Bérangère Bertin,Isidore Mushimiyimana,Monique M. van Oers,Otto Wilhelm Merten +7 more
TL;DR: It is shown that the baculoviral cathepsin (v-CATH) protease is active on several (but not all) rAAV serotypes, leading to a partial degradation of VP1/VP2 AAV capsid proteins, and it is demonstrated that the cleavage is highly specific.
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Muscle-specific, liver-detargeted AAV gene therapy rescues Pompe phenotype in adult and neonate Gaa-/- mice.
Pauline Sellier,Patrice Vidal,Bérangère Bertin,Evelyne Gicquel,Christophe Georger,Laetitia van Wittenberghe,Alejandra Miranda,Nathalie Daniele,Isabelle Richard,David-Alexandre Gross,Federico Mingozzi,Fanny Collaud,Giuseppe Ronzitti +12 more
TL;DR: In this article , a muscle-specific AAV capsid-promoter combination for the full rescue of Pompe disease manifestation in both neonate and adult Gaa-/- provides a potential therapeutic avenue for the infantile-onset form of this devastating disease.
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Patent
Method for removing anti-aav antibodies from a blood-derived composition
Bérangère Bertin,Carole Masurier,Otto-Wilhelm Merten,Federico Mingozzi +3 more
- 01 Mar 2018
TL;DR: In this article, a method for removing undesired anti-AAV antibodies from a blood-derived composition was proposed, which can be used to remove unwanted anti-ABV antibodies.
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Epitope Mapping by Molecular Imprinting of Adeno-Associated Virus Serotype 8(AAV8)-Antibody Complexes and Use of Fab Peptides as a Novel Strategy of Evadingneutralisation to Improve the Efficiency of AAV8-Mediated Gene Therapy
Elena V. Piletska,Philippe Veron,Bérangère Bertin,Federico Mingozzi,Donald Jones,Joseph Earley,Kal Karim,Alvaro Garcia Cruz,Sergey A. Piletsky +8 more