Benoit Moindrot
University of Oxford
8 Papers
12 Citations
Benoit Moindrot is an academic researcher from University of Oxford. The author has contributed to research in topics: XIST & X-inactivation. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Benoit Moindrot include University of Paris-Sud & Université Paris-Saclay.
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Papers
hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.
Greta Pintacuda,Guifeng Wei,Chloë Roustan,Burcu Anil Kirmizitas,Nicolae Solcan,Andrea Cerase,Alfredo Castello,Shabaz Mohammed,Benoit Moindrot,Tatyana B. Nesterova,Neil Brockdorff +10 more
TL;DR: The RNA-binding protein hnRNPK is identified as the principal XR-PID binding factor required to recruit PCGF3/5-PRC1, providing important insights into mechanisms of chromatin modification by non-coding RNA.
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A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing
Benoit Moindrot,Andrea Cerase,Heather Coker,Osamu Masui,Anne Grijzenhout,Greta Pintacuda,Lothar Schermelleh,Tatyana B. Nesterova,Neil Brockdorff +8 more
TL;DR: An shRNA screening strategy is developed to produce a ranked list of candidate primary silencing factors and it is demonstrated that the SPOC domain RNA binding proteins Rbm15 and Spen and Wtap, a component of the m6A RNA methyltransferase complex, as playing an important role in the establishment of Xist-mediated silencing.
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The role of the Xist 5' m6A region and RBM15 in X chromosome inactivation
Heather Coker,Guifeng Wei,Benoit Moindrot,Benoit Moindrot,Shabaz Mohammed,Tatyana B. Nesterova,Neil Brockdorff +6 more
- 17 Feb 2020
TL;DR: It is shown that in mESCs, RBM15 interacts with the m6A complex, the SETD1B histone modifying complex, and several proteins linked to RNA metabolism, and that this region plays a role in Xist-mediated chromosome silencing.
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RNA binding proteins implicated in Xist-mediated chromosome silencing.
Benoit Moindrot,Neil Brockdorff +1 more
TL;DR: Findings in this review are discussed in light of prior knowledge both of Xist-mediated silencing and known functions/properties of the novel factors.
40
Systematic Allelic Analysis Defines the Interplay of Key Pathways in X Chromosome Inactivation
Tatyana B. Nesterova,Guifeng Wei,Heather Coker,Greta Pintacuda,Joseph S Bowness,Tianyi Zhang,Mafalda Almeida,Bianca Bloechl,Benoit Moindrot,Emma J. Carter,Ines Alvarez Rodrigo,Qi Pan,Ying Bi,Chun-Xiao Song,Neil Brockdorff +14 more
TL;DR: A systematic analysis of Xist-mediated allelic silencing in ES cell-based models shows that Spen, recruited through the Xist A-repeat, plays a central role, being critical for silencing of all except a subset of weakly expressed genes.