Benoit Delache
University of Paris-Sud
24 Papers
177 Citations
Benoit Delache is an academic researcher from University of Paris-Sud. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 16 publications. Previous affiliations of Benoit Delache include International Practical Shooting Confederation & French Alternative Energies and Atomic Energy Commission.
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Papers
Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
Karine Labadie,Thibaut Larcher,Christophe Joubert,Abdelkrim Mannioui,Benoit Delache,Patricia Brochard,Lydie Guigand,Laurence Dubreil,Pierre Lebon,Bernard Verrier,Xavier de Lamballerie,Andreas Suhrbier,Yan Cherel,Roger Le Grand,Pierre Roques +14 more
TL;DR: In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting CHikV disease symptoms observed in humans.
Capsid-specific removal of circulating antibodies to adeno-associated virus vectors
Bérangère Bertin,Philippe Veron,Christian Leborgne,Jack-Yves Deschamps,Sophie Moullec,Yves Fromes,Fanny Collaud,Sylvie Boutin,Virginie Latournerie,Laetitia van Wittenberghe,Benoit Delache,Roger Le Grand,Nathalie Dereuddre-Bosquet,Olivier Benveniste,Philippe Moullier,Carole Masurier,Otto Wilhelm Merten,Federico Mingozzi +17 more
TL;DR: An AAV-specific plasmapheresis column was developed which was shown to efficiently and selectively deplete anti-AAV antibodies without depleting the total immunoglobulin pool from plasma, providing proof-of-concept of a method for the A AV-specific depletion of neutralizing antibodies in the setting of in vivo gene transfer.
Dynamics of T-Cell Responses and Memory T Cells during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques
Ingrid Karlsson,Benoit Malleret,Patricia Brochard,Benoit Delache,Julien Calvo,Roger Le Grand,Roger Le Grand,Bruno Vaslin,Bruno Vaslin +8 more
TL;DR: An inverse relationship between plasma viral load and the simian immunodeficiency virus (SIV)-specific T cells responses in peripheral blood and lymph nodes is found and details about the changes of virus-specific immune responses over time are provided.
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FoxP3+ CD25+ CD8+ T-Cell Induction during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques Correlates with Low CD4+ T-Cell Activation and High Viral Load
Ingrid Karlsson,Benoit Malleret,Patricia Brochard,Benoit Delache,Julien Calvo,Roger Le Grand,Roger Le Grand,Bruno Vaslin,Bruno Vaslin +8 more
TL;DR: The dynamics of CD25+ FoxP3+ T cells during primary and chronic SIVmac251 infection in cynomolgus macaques were monitored and the number of these cells was positively correlated with viral load and negatively correlated with CD4+ T-cell activation, SIV antigen-specific proliferative responses during primary infection, and plasma viral load at set point.
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Effect of SIVmac infection on plasmacytoid and CD1c+ myeloid dendritic cells in cynomolgus macaques
Benoit Malleret,Ingrid Karlsson,Benjamin Manéglier,Patricia Brochard,Benoit Delache,Thibault Andrieu,Michaela Müller-Trutwin,Tim Beaumont,Joseph M. McCune,Jacques Banchereau,Roger Le Grand,Roger Le Grand,Bruno Vaslin,Bruno Vaslin +13 more
TL;DR: Information regarding absolute pDC and mDC counts in non‐human primates may improve the understanding of the role of these cells in SIV/HIV infection and in other infectious diseases.
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