Benoit Cox
Katholieke Universiteit Leuven
10 Papers
1 Citations
Benoit Cox is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Stem cell & Organoid. The author has an hindex of 7, co-authored 8 publications.
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Papers
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening
Matteo Boretto,Nina Maenhoudt,Xinlong Luo,Aurélie Hennes,Bram Boeckx,Bich Bui,Bich Bui,R. Heremans,Lisa Perneel,Hiroto Kobayashi,Hiroto Kobayashi,Indra Van Zundert,Hilde Brems,Benoit Cox,Marc Ferrante,Hiroshi Uji-i,Kian Peng Koh,Thomas D'Hooghe,Arne Vanhie,Ignace Vergote,Christel Meuleman,Carla Tomassetti,Diether Lambrechts,Joris Vriens,Dirk Timmerman,Hugo Vankelecom +25 more
TL;DR: It is demonstrated that organoids derived from patients with various types of endometrial pathologies can model disease traits and diversity, and can be used as a drug-screening tool.
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Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability
Matteo Boretto,Benoit Cox,Manuel Noben,Nikolai Hendriks,Amelie Fassbender,Heleen Roose,Frédéric Amant,Frédéric Amant,Dirk Timmerman,Carla Tomassetti,Arne Vanhie,Christel Meuleman,Marc Ferrante,Hugo Vankelecom +13 more
TL;DR: An organoid culture system for endometrium is established, reproducing tissue epithelium physiology and allowing long-term expansion, and provides a powerful tool for studying mechanisms underlying the biology as well as the pathology of this key reproductive organ.
322
Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models.
Nina Maenhoudt,Charlotte Defraye,Matteo Boretto,Ziga Jan,R. Heremans,Bram Boeckx,Florian Hermans,Florian Hermans,Ingrid Arijs,Benoit Cox,Els Van Nieuwenhuysen,Ignace Vergote,Anne-Sophie Van Rompuy,Diether Lambrechts,Dirk Timmerman,Hugo Vankelecom +15 more
TL;DR: Established organoid lines from patient-derived OC showed patient tumor-dependent morphology and disease characteristics, and recapitulated the parent tumor's marker expression and mutational landscape, and displayed tumor-specific sensitivity to clinical HGSOC chemotherapeutic drugs.
141
Regeneration in the Pituitary After Cell-Ablation Injury: Time-Related Aspects and Molecular Analysis.
Christophe Willems,Qiuli Fu,Qiuli Fu,Heleen Roose,Freya Mertens,Benoit Cox,Jianghai Chen,Jianghai Chen,Hugo Vankelecom +8 more
TL;DR: Together, the regenerative capacity of the pituitary is limited both in age-related terms and final efficacy, and appears to rely on stem cell-associated pathway activation.
Organoids from pituitary as a novel research model toward pituitary stem cell exploration.
Benoit Cox,Emma Laporte,Annelies Vennekens,Hiroto Kobayashi,Hiroto Kobayashi,Charlotte Nys,Indra Van Zundert,Hiroshi Uji-i,Alizée Vercauteren Drubbel,Benjamin Beck,Heleen Roose,Matteo Boretto,Hugo Vankelecom +12 more
TL;DR: A novel organoid research model is established revealing new insights into the identity and regulation of the putative pituitary stem cells, which may eventually lead to an interesting tool to decipher pituitsary stem cell biology in both healthy and diseased gland.