Benjamin Strobel
Boehringer Ingelheim
23 Papers
1 Citations
Benjamin Strobel is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 16 publications. Previous affiliations of Benjamin Strobel include Harvard University.
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Papers
TDP-43 is intercellularly transmitted across axon terminals
Marisa S. Feiler,Benjamin Strobel,Axel Freischmidt,Anika M. Helferich,Julia Kappel,Bryson M. Brewer,Deyu Li,Dietmar Rudolf Thal,Paul Walther,Albert C. Ludolph,Karin M Danzer,Jochen H. Weishaupt +11 more
TL;DR: A protein complementation assay quantifying TDP-43 oligomerization in living neurons shows microvesicular and bidirectional synaptic transmission of TDP -43 and T DP-43 seeding activity in human ALS postmortem brain tissue.
Auto Poisoning of the Respiratory Chain by a Quorum-Sensing-Regulated Molecule Favors Biofilm Formation and Antibiotic Tolerance.
Ronen Hazan,Ronen Hazan,Yok-Ai Que,Yok-Ai Que,Damien Maura,Damien Maura,Benjamin Strobel,Paul Majcherczyk,Laura Rose Hopper,David J. Wilbur,Teri N. Hreha,Blanca Barquera,Laurence G. Rahme,Laurence G. Rahme +13 more
TL;DR: 2-n-heptyl-4-hydroxyquinoline-N-oxide (HQNO), a Pseudomonas aeruginosa quorum-sensing-regulated low-molecular-weight excreted molecule, triggers autolysis by self-perturbing the electron transfer reactions of the cytochrome bc1 complex, which suggests intriguing mechanistic similarities with the initial mitochondrial-mediated steps of eukaryotic apoptosis.
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Comparative Analysis of Cesium Chloride- and Iodixanol-Based Purification of Recombinant Adeno-Associated Viral Vectors for Preclinical Applications
TL;DR: This study conducts a side-by-side comparison of the CsCl and iodixanol/ultrafiltration protocol and identifies prominent protein impurities in the AAV vector product, thereby identifying known and new, possibly AAV-interacting proteins as major contaminants.
151
Peripheral monocytes are functionally altered and invade the CNS in ALS patients
Lisa Zondler,Kathrin Muller,Samira Khalaji,Corinna Bliederhäuser,Wolfgang Ruf,Veselin Grozdanov,Meinolf Thiemann,Katrin Fundel-Clemes,Axel Freischmidt,Karlheinz Holzmann,Benjamin Strobel,Patrick Weydt,Anke Witting,Dietmar Rudolf Thal,Anika M. Helferich,Bastian Hengerer,Kay-Eberhard Gottschalk,Oliver Hill,Michael Kluge,Albert C. Ludolph,Karin M Danzer,Jochen H. Weishaupt +21 more
TL;DR: The circulating monocytes are found to be deregulated in ALS regarding subtype constitution, function and gene expression and application of human immunoglobulins or fusion proteins containing only the human Fc, but not the Fab antibody fragment increased CNS invasion of peripheral monocytes and delayed the disease onset.
135
Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis
Verena Aumiller,Benjamin Strobel,Merrit Romeike,Michael Schuler,Birgit Stierstorfer,Sebastian Kreuz +5 more
TL;DR: This study provides a comprehensive analysis of theLOX/L family in fibrotic lung disease and indicates prominent roles for LOXL2/3 in fibroblast activation and LOX/LOXL2 in IPF.