Benjamin K. Johnson
Van Andel Institute
39 Papers
75 Citations
Benjamin K. Johnson is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Biology & DNA methylation. The author has an hindex of 14, co-authored 32 publications. Previous affiliations of Benjamin K. Johnson include Calvin College & Michigan State University.
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Papers
Slow growth of Mycobacterium tuberculosis at acidic pH is regulated by phoPR and host‐associated carbon sources
TL;DR: It is reported that Mycobacterium tuberculosis growth at acidic pH requires host‐associated carbon sources that function at the intersection of glycolysis and the TCA cycle, such as pyruvate, acetate, oxaloacetate and cholesterol, and it is demonstrated that the phoPR two‐component regulatory system is required to slow Mtb growth at acid pH and functions to maintain redox homeostasis.
Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence.
Huiqing Zheng,Christopher J. Colvin,Benjamin K. Johnson,Paul D. Kirchhoff,Michael Wilson,Katriana Jorgensen-Muga,Scott D. Larsen,Robert B. Abramovitch +7 more
TL;DR: Novel inhibitors of the DosRST regulon are discovered, including artemisinin, HC102A and HC103A, which inhibit Mtb-persistence-associated physiological processes, including triacylglycerol synthesis, survival and antibiotic tolerance.
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Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.
Megan M. Senchuk,Dylan J. Dues,Claire E. Schaar,Benjamin K. Johnson,Zachary Madaj,Megan J. Bowman,Mary E. Winn,Jeremy M. Van Raamsdonk,Jeremy M. Van Raamsdonk,Jeremy M. Van Raamsdonk +9 more
TL;DR: This work reveals an overlapping genetic pathway required for longevity in three mitochondrial mutants, and demonstrates that DAF-16 is a downstream mediator of lifespan extension in multiple pathways of longevity.
The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence
Benjamin K. Johnson,Christopher J. Colvin,David B. Needle,Felix Mba Medie,Patricia A. DiGiuseppe Champion,Robert B. Abramovitch +5 more
TL;DR: It is proposed that ethoxzolamide may be pursued as a new class of antivirulence therapy that functions by modulating expression of the PhoPR regulon and Esx-1-dependent virulence.
Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.
Ziyun Wu,Ziyun Wu,Megan M. Senchuk,Dylan J. Dues,Benjamin K. Johnson,Jason F. Cooper,Leira Lew,Emily Machiela,Claire E. Schaar,Heather DeJonge,T. Keith Blackwell,T. Keith Blackwell,Jeremy M. Van Raamsdonk +12 more
TL;DR: It is suggested that the mitoUPR causes atfs-1-dependent changes in the expression of genes involved in stress response and metabolism, which contributes to the extended longevity observed in this mutant.