Benjamin J. Morrow
Queensland University of Technology
9 Papers
16 Citations
Benjamin J. Morrow is an academic researcher from Queensland University of Technology. The author has contributed to research in topics: Nitroxide mediated radical polymerization & Chemistry. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Benjamin J. Morrow include Australian National University.
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Papers
Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides
Hyo Yang Ahn,Kathryn E. Fairfull-Smith,Benjamin J. Morrow,Vanessa C. Lussini,Bosung Kim,Mykhailo V. Bondar,Steven E. Bottle,Kevin D. Belfield +7 more
TL;DR: A range of varying chromophore nitroxide free radicals and their nonradical methoxyamine analogues were synthesized and their linear photophysical properties examined in this article, where two nitroxides incorporating anthracene and fluorescein chromophores (compounds 7 and 19, respectively) exhibited two-photon absorption (2PA) cross sections of approximately 400 G.M. when excited at wavelengths greater than 800 nm.
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Profluorescent Nitroxides as Sensitive Probes of Oxidative Change and Free Radical Reactions
TL;DR: A review on the use of tethered nitroxide-fluorophore molecules as probes of oxidative change and free radical generation and reaction can be found in this article, where a survey of profluorescent nitroxides is provided as well as background on the mechanism of action and applications of these compounds as fluorometric probes within the fields of biological, materials and environmental sciences.
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•Journal Article
Two-Photon Fluorescence Microscopy Imaging of Cellular Oxidative Stress Using Profluorescent Nitroxides
Hyo Yang Ahn,Kathryn E. Fairfull-Smith,Benjamin J. Morrow,Vanessa C. Lussini,Bosung Kim,Mykhailo V. Bondar,Steven E. Bottle,Kevin D. Belfield +7 more
TL;DR: The high ratio of the fluorescence quantum yield between the profluorescent nitroxide species and their nonradical adducts provides the sensitivity required for measuring a range of cellular redox environments, and their reasonable 2PA cross sections provide for the option of using two-photon fluorescence microscopy.
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Pro-fluorescent mitochondria-targeted real-time responsive redox probes synthesised from carboxy isoindoline nitroxides: Sensitive probes of mitochondrial redox status in cells.
Kok Leong Chong,Benjamin A. Chalmers,Jason K. Cullen,Amandeep Kaur,Jacek L. Kolanowski,Benjamin J. Morrow,Kathryn E. Fairfull-Smith,Martin J Lavin,Nigel L. Barnett,Elizabeth J. New,Michael P. Murphy,Steven E. Bottle +11 more
TL;DR: In this paper, the authors describe new fluorescent probes based on fluorescein and rhodamine that provide reversible, real-time insight into cellular redox status, which can be used to detect response to redox stress within cells as analysed by flow cytometry.
16
Evidence for the in Vitro Bioactivation of Aminopyrazole Derivatives: Trapping Reactive Aminopyrazole Intermediates Using Glutathione Ethyl Ester in Human Liver Microsomes
Eileen Ryan,Benjamin J. Morrow,Catherine Fae Hemley,Jo-Anne Pinson,Susan A. Charman,Francis C. K. Chiu,Richard C. Foitzik +6 more
TL;DR: Evidence is presented for the bioactivation of a series of aminopyrazole derivatives via LC-MS detection of glutathione ethyl ester-trapped reactive intermediates formed in human liver microsomal incubations that indicate that the aminogyrazole motif, within specific contexts, may be considered a new structural alert for the potential formation of reactive metabolites.
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