Benjamin Fourneaux
University of Bordeaux
5 Papers
Benjamin Fourneaux is an academic researcher from University of Bordeaux. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Cancer stem cell. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Benjamin Fourneaux include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Papers
MDM2 antagonists synergize with PI3K/mTOR inhibition in well-differentiated/dedifferentiated liposarcomas.
Audrey Laroche,Audrey Laroche,Vanessa Chaire,Vanessa Chaire,Marie-Paule Algeo,Marie Karanian,Benjamin Fourneaux,Benjamin Fourneaux,Antoine Italiano +8 more
TL;DR: The results represent the first in vivo evidence of synergy between MDM2 and PI3K/AKT/mTOR antagonists and represent a strong rationale to evaluate the therapeutic potential of such a combination in WDLPS/DDLPS.
Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications.
Benjamin Fourneaux,Benjamin Fourneaux,Vanessa Chaire,Vanessa Chaire,Carlo Lucchesi,Marie Karanian,Raphael Pineau,Audrey Laroche-Clary,Audrey Laroche-Clary,Antoine Italiano +9 more
TL;DR: It is document for the first time that dual PI3K/mTOR inhibition in leiomyosarcomas suppress a negative feedback loop mediated by mTORC2, leading to enhanced ERK pathway activity.
Expression of Concern to: Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K/mTOR inhibition.
Benjamin Fourneaux,Benjamin Fourneaux,Aurélien Bourdon,Bérengère Dadone,Carlo Lucchesi,Scott R. Daigle,Elodie Richard,Elodie Richard,Audrey Laroche-Clary,Audrey Laroche-Clary,François Le Loarer,Antoine Italiano +11 more
TL;DR: The Editor-in-Chief would like to alert readers that the ownership of some of the data presented in this article is the property of the author and not the publisher.
Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K/mTOR inhibition
Benjamin Fourneaux,Benjamin Fourneaux,Aurélien Bourdon,Bérengère Dadone,Carlo Lucchesi,Scott R. Daigle,Elodie Richard,Elodie Richard,Audrey Laroche-Clary,Audrey Laroche-Clary,François Le Loarer,Antoine Italiano +11 more
TL;DR: It is suggested that CSCs have a strong impact on the outcome of patients with LMS and that combining PI3K/mTOR and EZH2 inhibitors may represent a promising strategy in this setting.
Why am I lost without dopamine? Effects of 6-OHDA lesion on the encoding of reward and decision process in CA3
Aude Retailleau,Aude Retailleau,Cyril Dejean,Cyril Dejean,Benjamin Fourneaux,Benjamin Fourneaux,Xavier Leinekugel,Xavier Leinekugel,Thomas Boraud,Thomas Boraud +9 more
TL;DR: This work addressed the issue of multiple electrode recordings of CA3 in normal and dopamine depleted rats performing a spatial learning in a Y-maze and confirmed that DA is essential to spatial learning as its depletion results in spatial impairments.