Benjamin Forbes
Harvard University
4 Papers
Benjamin Forbes is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & CXCR4. The author has an hindex of 4, co-authored 4 publications.
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Papers
CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer
Elda Righi,Satoshi Kashiwagi,Jianping Yuan,Michael Santosuosso,Pierre Leblanc,Rachel Ingraham,Benjamin Forbes,Beth Edelblute,Brian Collette,Deyin Xing,Magdalena Kowalski,Magdalena Kowalski,Maria Cristina Mingari,Fabrizio Vianello,Michael J. Birrer,Sandra Orsulic,Sandra Orsulic,Glenn Dranoff,Mark C. Poznansky +18 more
TL;DR: Modulation of the CXCL12/CXCR4 axis in ovarian cancer has multimodal effects on tumor pathogenesis associated with induction of antitumor immunity and offers a definitive preclinical validation of CX CR4 as a therapeutic target in this disease.
Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine.
Kaitlyn Morse,Yoshifumi Kimizuka,Megan P. K. Chan,Mai Shibata,Yusuke Shimaoka,Shu Takeuchi,Benjamin Forbes,Christopher J. Nirschl,Binghao Li,Yang Zeng,Roderick T. Bronson,Wataru Katagiri,Ayako Shigeta,Ruxandra F. Sîrbulescu,Huabiao Chen,Rhea Y. Y. Tan,Kosuke Tsukada,Timothy Brauns,Jeffrey A. Gelfand,Ann E. Sluder,Joseph J. Locascio,Mark C. Poznansky,Niroshana Anandasabapathy,Satoshi Kashiwagi +23 more
TL;DR: It is found that a continuous wave (CW) NIR laser adjuvant broadly modulates migratory DC (migDC) populations, specifically increasing and activating the Lang+ and CD11b−Lang− subsets in skin, and that the Ab responses augmented by the CW Nir laser are dependent on DC subsets expressing CCR2 and Langerin.
Near-infrared laser adjuvant for influenza vaccine.
Satoshi Kashiwagi,Jianping Yuan,Benjamin Forbes,Mathew L. Hibert,Eugene L. Q. Lee,Laura Whicher,Calum Goudie,Yuan Yang,Tao Chen,Beth Edelblute,Brian Collette,Laurel Edington,James T. Trussler,Jean Nezivar,Pierre Leblanc,Roderick T. Bronson,Kosuke Tsukada,Makoto Suematsu,Jeffrey S. Dover,Timothy Brauns,Jeffrey A. Gelfand,Mark C. Poznansky +21 more
TL;DR: It is shown that non-tissue damaging, near-infrared (NIR) laser light given in short exposures to small areas of skin, without the use of additional chemical or biological agents, significantly increases immune responses to intradermal influenza vaccination without augmenting IgE.
Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression.
Tao Chen,Jason X.-J. Yuan,Stephanie Duncanson,Mathew L. Hibert,Brett Kodish,G. Mylavaganam,Michael Maker,Hao Wei Li,Marinko Sremac,Michael Santosuosso,Benjamin Forbes,Satoshi Kashiwagi,J. Cao,Ji Lei,M. Thomas,Choli Hartono,David H. Sachs,James F. Markmann,Athanassios Sambanis,Mark C. Poznansky +19 more
TL;DR: The use of CXCL12 as a coating or a component of an alginate encapsulant to induce sustained local immune‐isolation for allo‐ or xenoislet transplantation without systemic immunosuppression is supported.